ArticleGenetics2012
The genetic consequences of spatially varying selection in the panmictic American eel (Anguilla rostrata).
Article in Genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
- Genomic Footprints of Hybridisation in North Atlantic Eels (Anguilla anguilla and A. rostrata).Molecular ecology · 2025Article
- Genetic adaptation despite high gene flow in a range-expanding population.Molecular ecology · 2025Article
- Hierarchical Neutral and Non-Neutral Spatial Genetic Structuring in the European Sardine (Evolutionary applications · 2025Article
- Exploring the importance of predicted camel NRAP exon 4 for environmental adaptation using a mouse model.Animal genetics · 2025Article
- Phenotypic and Genomic Signatures of Latitudinal Local Adaptation Along With Prevailing Ocean Current in a Coastal Goby.Molecular ecology · 2025Article
- DNA methylation patterns linked to salinity and geography in the American eel (Environmental epigenetics · 2025Article
- Genetic architecture of long-distance migration and population genomics of the endangered Japanese eel.iScience · 2024Article
- Panmixia in the American eel extends to its tropical range of distribution: Biological implications and policymaking challenges.Evolutionary applications · 2023Article
- Seascape genomics reveals limited dispersal and suggests spatially varying selection among European populations of sea lamprey (Evolutionary applications · 2023Article
- Spatially varying selection between habitats drives physiological shifts and local adaptation in a broadcast spawning coral on a remote atoll in Western Australia.Science advances · 2022Article
- Demographic History, Adaptation, and NRAP Convergent Evolution at Amino Acid Residue 100 in the World Northernmost Cattle from Siberia.Molecular biology and evolution · 2021Article
- Parallel selection on ecologically relevant gene functions in the transcriptomes of highly diversifying salmonids.BMC genomics · 2019Article
- Standing genetic variation fuels rapid adaptation to ocean acidification.Nature communications · 2019Article
- Article
- Genomic signatures of environmental selection despite near-panmixia in summer flounder.Evolutionary applications · 2018Article
- Article
- RAD-Seq Reveals Patterns of Additive Polygenic Variation Caused by Spatially-Varying Selection in the American Eel (Anguilla rostrata).Genome biology and evolution · 2017Article
- Range-wide parallel climate-associated genomic clines in Atlantic salmon.Royal Society open science · 2017Article
- Article
- Detecting polygenic selection in marine populations by combining population genomics and quantitative genetics approaches.Current zoology · 2016Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Our understanding of the genetic basis of local adaptation has recently benefited from the increased power to identify functional variants associated with environmental variables at the genome scale. However, it often remains challenging to determine whether locally adaptive alleles are actively maintained at intermediate frequencies by spatially varying selection. Here, we evaluate the extent to which this particular type of balancing selection explains the retention of adaptive genetic variation in the extreme situation of perfect panmixia, using the American eel (Anguilla rostrata) as a model. We first conducted a genome scan between two samples from opposite ends of a latitudinal environmental gradient using 454 sequencing of individually tagged cDNA libraries. Candidate SNPs were then genotyped in 992 individuals from 16 sampling sites at different life stages of the same cohort (including larvae from the Sargasso Sea, glass eels, and 1-year-old individuals) as well as in glass eels of the following cohort. Evidence for spatially varying selection was found at 13 loci showing correlations between allele frequencies and environmental variables across the entire species range. Simulations under a multiple-niche Levene's model using estimated relative fitness values among genotypes rarely predicted a stable polymorphic equilibrium at these loci. Our results suggest that some genetic-by-environment interactions detected in our study arise during the progress toward fixation of a globally advantageous allele with spatially variable effects on fitness.
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