ReviewAmerican journal of respiratory and critical care medicine2012
Obstructive sleep apnea in infants.
Review in American journal of respiratory and critical care medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
82 citing papers in PubMed, 3 syntheses or guidelines pooled it, 248 citations in OpenAlex.
- Respiratory indices during sleep in healthy infants: A prospective longitudinal study and meta-analysis.Sleep medicine · 2022Pooled it
- Association between active tobacco use during pregnancy and infant respiratory health: a systematic review and meta-analysis.BMJ open · 2020Pooled it
- Sleep and respiratory outcomes in neonates with Pierre Robin sequence: a concise review.Sleep & breathing = Schlaf & Atmung · 2020Pooled it
- Drug-Induced Sleep Endoscopy in Infants With Obstructive Sleep Apnea: Current Evidence and Knowledge Gaps.Laryngoscope investigative otolaryngology · 2026Review
- Automatic annotation to train ROI detection algorithm for premature infant respiration monitoring in NICU.Medical & biological engineering & computing · 2026Article
- Obstructive Sleep Apnea and Cardiovascular Disease: Mechanisms, Diagnostics, and Emerging Therapeutic Approaches.Biomedicines · 2026Review
- Home Oxygen Use and Post-Discharge Management of Infants with Bronchopulmonary Dysplasia.Clinics in perinatology · 2026Review
- Is Surgical Treatment for Obstructive Sleep Apnea in Infants and Toddlers Safe? A Retrospective Comparative Analysis.Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery · 2026Article
- Predicting surgical intervention in infants with laryngomalacia.International journal of pediatric otorhinolaryngology · 2025Article
- Failure of Mandibular Distraction Osteogenesis in Klippel- Feil Syndrome- 4: A Case Report of a Rare Syndromic Robin Sequence.The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association · 2025Article
- Sleep-related breathing disorders in infants with spina bifida repaired prenatally and postnatally.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2024Article
- Sex differences in cardiac transcriptomic response to neonatal sleep apnea.Physiological reports · 2024Article
- Clinical characteristics, associated comorbidities and hospital outcomes of neonates with sleep disordered breathing: a retrospective cohort study.BMJ paediatrics open · 2024Article
- Polysomnogram outcomes in patients with laryngomalacia and obstructive sleep apnoea treated surgically versus non-surgically.The Journal of laryngology and otology · 2024Article
- Laryngomalacia and Obstructive Sleep Apnea in Children: From Diagnosis to Treatment.Children (Basel, Switzerland) · 2024Review
- Accuracy of parental perception of nighttime breathing in children with Down syndrome after adenotonsillectomy.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2024Article
- Early-onset pharyngeal airway collapse in infants: a retrospective single-center study.BMC pediatrics · 2023Article
- MicroNAPS: A Novel Classification for Infants with Micrognathia, Robin Sequence, and Tongue-based Airway Obstruction.Plastic and reconstructive surgery. Global open · 2023Article
- Jak2 and Jaw Muscles Are Required for Buccopharyngeal Membrane Perforation during Mouth Development.Journal of developmental biology · 2023Article
- Obstructive sleep apnea is position dependent in young infants.Pediatric research · 2023Article
22 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
Obstructive sleep apnea in infants has a distinctive pathophysiology, natural history, and treatment compared with that of older children and adults. Infants have both anatomical and physiological predispositions toward airway obstruction and gas exchange abnormalities; including a superiorly placed larynx, increased chest wall compliance, ventilation-perfusion mismatching, and ventilatory control instability. Congenital abnormalities of the airway, such as laryngomalacia, hemangiomas, pyriform aperture stenosis, choanal atresia, and laryngeal webs, may also have adverse effects on airway patency. Additional exacerbating factors predisposing infants toward airway collapse include neck flexion, airway secretions, gastroesophageal reflux, and sleep deprivation. Obstructive sleep apnea in infants has been associated with failure to thrive, behavioral deficits, and sudden infant death. The proper interpretation of infant polysomnography requires an understanding of normative data related to gestation and postconceptual age for apnea, arousal, and oxygenation. Direct visualization of the upper airway is an important diagnostic modality in infants with obstructive apnea. Treatment options for infant obstructive sleep apnea are predicated on the underlying etiology, including supraglottoplasty for severe laryngomalacia, mandibular distraction for micrognathia, tonsillectomy and/or adenoidectomy, choanal atresia repair, and/or treatment of gastroesophageal reflux.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.