Evidence map›Paper›PMID 22134972›Full record

ArticleChembiochem : a European journal of chemical biology2012

Inhibition of heat shock transcription factor binding by a linear polyamide binding in an unusual 1:1 mode.

Rongsheng E Wang, Raj K Pandita, Jianfeng Cai, Clayton R Hunt, John-Stephen Taylor

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chembiochem : a European journal of chemical biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Rongsheng E WangDepartment of Chemistry, Washington University, St. Louis, MO 63130, USA.
Raj K Pandita
Jianfeng Cai
Clayton R Hunt
John-Stephen Taylor
Washington University in St. Louis · US

Funding

YOGA LIFESTYLE INTERVENTION REDUCES BLOOD PRESSURE IN HIV-INFECTED ADULTSP41RR000954 · NCRR · WASHINGTON UNIVERSITY · PI GROSS, MICHAEL L · 1985 to 2011
$16.0M
Tumor Cells Specific Targets for Combined Heat/RadiationP01CA104457 · NCI · WASHINGTON UNIVERSITY · PI ROTI ROTI, JOSEPH L · 2004 to 2008
$8.4M
REQUEST TO UPGRADE 600 MHZ NMR SYSTEMS10RR015715 · NCRR · WASHINGTON UNIVERSITY · PI ACKERMAN, JOSEPH J. H. · 2001 to 2001
$488k
NCI NIH HHS P01 CA 104457NCI NIH HHS P01 CA104457NCRR NIH HHS P41 RR000954NCRR NIH HHS RR1571501
6 · The paper itself

Abstract

Heat shock proteins (HSPs) are known to protect cells from heat, oxidative stress, and the cytotoxic effects of drugs, and thus can enhance cancer cell survival. As a result, HSPs are a newly emerging class of protein targets for chemotherapy. Among the various HSPs, the HSP70 family is the most highly conserved and prevalent. Herein we describe the development of a β-alanine rich linear polyamide that binds the GGA heat shock elements (HSEs) 3 and 4 in the HSP70 promoter in an unusual 1:1 mode and inhibits heat shock transcription factor 1 (HSF1) binding in vitro.

Indexed as

Binding SitesDNA-Binding ProteinsHeat Shock Transcription FactorsHumansMolecular StructureNylonsProtein IsoformsStructure-Activity RelationshipTranscription FactorsDNA-Binding ProteinsHeat Shock Transcription FactorsHSF1 protein, humanNylonsProtein IsoformsTranscription Factors

Identifiers

PMID22134972
PMCPMC3516905
OpenAlexW2017482875

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.