ReviewMayo Clinic proceedings2011
Rethinking cocaine-associated chest pain and acute coronary syndromes.
Review in Mayo Clinic proceedings, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Cocaine, cardiomyopathy, and heart failure: a systematic review and meta-analysis.Scientific reports · 2020Pooled it
- Application of European Society of Cardiology guidelines for evaluating acute coronary syndrome risk in low-risk patients with cocaine-associated chest pain: Findings from the RISK study - An observational analysis.Toxicology reports · 2024Article
- Neurovascular effects of cocaine: relevance to addiction.Frontiers in pharmacology · 2024Review
- Article
- Necrotizing Esophagitis: A Big Squeeze?Journal of the Canadian Association of Gastroenterology · 2022Article
- A young patient with acute myocardial infarction due to bonsai treated with glycoprotein IIbIIIa inhibitor.Anatolian journal of cardiology · 2021Article
- Risk and Protective Factors of Lifetime Cocaine-Associated Chest Pain.Frontiers in psychiatry · 2021Article
- Carvedilol Among Patients With Heart Failure With a Cocaine-Use Disorder.JACC. Heart failure · 2019Observational
- Cocaine Abuse: An Attack to the Cardiovascular System-Insights from Cardiovascular MRI.Radiology. Cardiothoracic imaging · 2019Review
- Imaging plaque inflammation in asymptomatic cocaine addicted individuals with simultaneous positron emission tomography/magnetic resonance imaging.World journal of radiology · 2019Article
- Acute renal infarction, transient ischemic attack, and biventricular thrombi secondary to substance use disorder: A case report.Clinical case reports · 2019Article
- In-Hospital and Long-Term Outcomes of Beta-Blocker Treatment in Cocaine Users: A Systematic Review and Meta-analysis.Cardiology research · 2019Article
- Cocaine Positivity in ST-Elevation Myocardial Infarction: A True or False Association.The Permanente journal · 2019Article
- Sympathomimetic Toxidromes and Other Pharmacological Causes of Acute Hypertension.Current hypertension reports · 2018Review
- Vascular disease in cocaine addiction.Atherosclerosis · 2017Review
- Cocaine-Levamisole-Induced Vasculitis/Vasculopathy Syndrome.Current rheumatology reports · 2017Review
- Sudden Cardiac Death of a Body Packer Due to Cocaine Cardiotoxicity.Clinical medicine insights. Pathology · 2016Article
- Clinical Comorbidities among Cocaine Users Screened in the Community through HealthStreet.Health behavior and policy review · 2016Article
- Cocaine use does not affect mean platelet volume.Interventional medicine & applied science · 2015Article
- Nonatherosclerotic causes of acute coronary syndrome: recognition and management.Current cardiology reports · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Every year more than 500,000 patients present to the emergency department with cocaine-associated complications, most commonly chest pain. Many of these patients undergo extensive work-up and treatment. Much of the evidence regarding cocaine's cardiovascular effects, as well as the current management of cocaine-associated chest pain and acute coronary syndromes, is anecdotally derived and based on studies written more than 2 decades ago that involved only a few patients. Newer studies have brought into question many of the commonly held theories and practices regarding the etiology, diagnosis, and treatment of this common clinical scenario. However, there continues to be a paucity of prospective, randomized trials addressing this topic as it relates to clinical outcomes. We searched PubMed for English-language articles from 1960 to 2011 using the keywords cocaine, chest pain, coronary arteries, myocardial infarction, emergency department, cardiac biomarkers, electrocardiogram, coronary computed tomography, observation unit, β-blockers, benzodiazepines, nitroglycerin, calcium channel blockers, phentolamine, and cardiomyopathy; including various combinations of these terms. We reviewed the abstracts to confirm relevance, and then full articles were extracted. References from extracted articles were also reviewed for relevant articles. In this review, we critically evaluate the limited historical evidence underlying the current teachings on cocaine's cardiovascular effects and management of cocaine-associated chest pain. We aim to update the reader on more recent, albeit small, studies on the emergency department evaluation and clinical and pharmacologic management of cocaine-associated chest pain. Finally, we summarize recent guidelines and review an algorithm based on the current best evidence.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.