ArticleThe Journal of biological chemistry2012
Dentin phosphoprotein (DPP) activates integrin-mediated anchorage-dependent signals in undifferentiated mesenchymal cells.
Article in The Journal of biological chemistry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 34 citations in OpenAlex.
- Comparison of periapical cyst- and dental pulp-derived mesenchymal stem cells: an in vitro study on proliferation, differentiation, migration, and odontogenic potential.In vitro cellular & developmental biology. Animal · 2026Article
- DPP-Mediated Interaction of TAZ/β-Catenin Promotes the Differentiation of DPSCs into Odontoblasts.International journal of molecular sciences · 2026Article
- Splicing mutation in DSPP causes dentinogenesis imperfecta and amelogenesis imperfecta.BMC oral health · 2026Article
- Identification of novel candidate genes associated with non-syndromic tooth agenesis in Mongolian families.Clinical oral investigations · 2023Article
- GRP78 promotes the osteogenic and angiogenic response in periodontal ligament stem cells.European cells & materials · 2023Article
- Dentine sialophosphoprotein signal in dentineogenesis and dentine regeneration.European cells & materials · 2021Review
- FAK, paxillin, and PI3K in ameloblastoma and adenomatoid odontogenic tumor.Clinical oral investigations · 2021Article
- Article
- Disentangling the complexity of low complexity proteins.Briefings in bioinformatics · 2020Review
- Endocytic Trafficking of DMP1 and GRP78 Complex Facilitates Osteogenic Differentiation of Human Periodontal Ligament Stem Cells.Frontiers in physiology · 2019Article
- The ER CaConnective tissue research · 2018Article
- Dentin sialoprotein facilitates dental mesenchymal cell differentiation and dentin formation.Scientific reports · 2017Article
- The Dentin Sialoprotein (DSP) Domain Regulates Dental Mesenchymal Cell Differentiation through a Novel Surface Receptor.Scientific reports · 2016Article
- Dentin Matrix Proteins in Bone Tissue Engineering.Advances in experimental medicine and biology · 2015Review
- Dentin phosphophoryn in the matrix activates AKT and mTOR signaling pathway to promote preodontoblast survival and differentiation.Frontiers in physiology · 2015Article
- Multifunctional ECM proteins in bone and teeth.Experimental cell research · 2014Review
- Adhesive and migratory effects of phosphophoryn are modulated by flanking peptides of the integrin binding motif.PloS one · 2014Article
- Odontogenic induction of dental stem cells by extracellular matrix-inspired three-dimensional scaffold.Tissue engineering. Part A · 2014Article
- Acidic domain in dentin phosphophoryn facilitates cellular uptake: implications in targeted protein delivery.The Journal of biological chemistry · 2013Article
- Dentin phosphophoryn activates Smad protein signaling through Ca2+-calmodulin-dependent protein kinase II in undifferentiated mesenchymal cells.The Journal of biological chemistry · 2013Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Dentin phosphoprotein (DPP), a major noncollagenous protein of the dentin matrix, is a highly acidic protein that binds Ca(2+) avidly and is thus linked to matrix mineralization. Here, we demonstrate that the RGD domain in DPP can bind to integrins on the cell surface of undifferentiated mesenchymal stem cells and pulp cells. This coupling generates intracellular signals that are channeled along cytoskeletal filaments and activate the non-receptor tyrosine kinase focal adhesion kinase, which plays a key role in signaling at sites of cellular adhesion. The putative focal adhesion kinase autophosphorylation site Tyr(397) is phosphorylated during focal adhesion assembly induced by DPP on the substrate. We further demonstrate that these intracellular signals propagate through the cytoplasm and activate anchorage-dependent ERK signaling. Activated ERK translocates to the nucleus and phosphorylates the transcription factor ELK-1, which in turn coordinates the expression of downstream target genes such as DMP1 and dentin sialoprotein (DSP). These studies suggest a novel paradigm demonstrating that extracellular DPP can induce intracellular signaling that can be propagated to the nucleus and thus alter gene activities.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.