ArticleJournal of neuro-oncology2012
Atypical teratoid/rhabdoid tumors: the need for more active therapeutic measures in younger patients.
Article in Journal of neuro-oncology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 20 citations in OpenAlex.
- Atypical Teratoid/Rhabdoid Tumor of the Central Nervous System in Children under the Age of 3 Years.Cancer research and treatment · 2021Article
- Effect of early radiotherapy initiation and high-dose chemotherapy on the prognosis of pediatric atypical teratoid rhabdoid tumors in different age groups.Journal of neuro-oncology · 2020Article
- Overall Survival of Primary Intracranial Atypical Teratoid Rhabdoid Tumor Following Multimodal Treatment: A Pooled Analysis of Individual Patient Data.Neurosurgical review · 2020Article
- Article
- Repositioning disulfiram as a radiosensitizer against atypical teratoid/rhabdoid tumor.Neuro-oncology · 2017Article
- Spinal cord gliosarcoma with rhabdomyoblastic differentiation: a case report.International journal of clinical and experimental pathology · 2017Article
- Magnetic Resonance Imaging Features of Rhabdoid Glioblastomas.Clinical neuroradiology · 2016Article
- One-year outcome of postoperative swallowing impairment in pediatric patients with posterior fossa brain tumor.Journal of neuro-oncology · 2016Article
- LIN28B is highly expressed in atypical teratoid/rhabdoid tumor (AT/RT) and suppressed through the restoration of SMARCB1.Cancer cell international · 2016Article
- Multimodal therapy in children and adolescents with newly diagnosed atypical teratoid rhabdoid tumor: individual pooled data analysis and review of the literature.Journal of neuro-oncology · 2016Review
- Disulfiram modulates stemness and metabolism of brain tumor initiating cells in atypical teratoid/rhabdoid tumors.Neuro-oncology · 2015Article
- Childhood brain tumor epidemiology: a brain tumor epidemiology consortium review.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2014Review
- The descriptive epidemiology of atypical teratoid/rhabdoid tumors in the United States, 2001-2010.Neuro-oncology · 2014Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite active and aggressive therapeutic measures, atypical teratoid/rhabdoid tumors (AT/RTs) are without doubt one of the most malignant brain tumors that occur during childhood. These tumors are more prevalent in children less than 3 years of age, and the prognosis is worse in these young children. Medical records of 14 patients diagnosed at our institution were reviewed. Patients diagnosed with AT/RT at our institution between 1997 and 2009 were identified. Clinical data for those patients with pathologic confirmation of AT/RTs were reviewed regarding surgery, adjuvant treatment, and survival. A total of 14 patients were identified. One patient who died 3 days after initial surgery was excluded, and 13 patients were recruited. Of the 13 patients, 7 were less than 1 year of age, and only 2 were over 3 years of age. Nine patients showed dissemination at diagnosis. Four patients were treated with radiation therapy (RTx), and 2 of these were less than 3 years of age. Ten patients had chemotherapy (CTx), and 3 of these underwent high dose chemotherapy and autologous peripheral blood stem cell transplantation. The median progression-free survival (PFS) was 4 months, and the median overall survival (OS) was 9 months. Univariable analysis revealed age more than 1 year, CTx, and RTx to be significant factors for better PFS and OS. None of the variables were significant in multivariable analysis. Young patients with AT/RT have a bad prognosis. An aggressive therapeutic strategy needs to be profiled for this age group.
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Registered trials
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