SynthesisGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2012
Plasma homocysteine, serum folic acid, serum vitamin B12, serum vitamin B6, MTHFR and risk of pseudoexfoliation glaucoma: a meta-analysis.
Synthesis in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 55 citations in OpenAlex.
- Analysis of genetically determined gene expression suggests role of inflammatory processes in exfoliation syndrome.BMC genomics · 2023Pooled it
- Pooled it
- Diet, Exercise, and Lifestyle in Glaucoma: Current Evidence and Future Perspectives.Nutrients · 2025Review
- Dysfunctional one-carbon metabolism identifies vitamins BCell reports. Medicine · 2025Article
- Associations of circulating vitamins with 10-year retinal neurodegeneration: the Alienor Study.The journal of nutrition, health & aging · 2024Article
- Association of dietary intake of B vitamins with glaucoma.Scientific reports · 2024Article
- Association Between High Blood Folate Levels and Glaucoma in a Representative Korean Population.Investigative ophthalmology & visual science · 2024Article
- Nutritional Factors: Benefits in Glaucoma and Ophthalmologic Pathologies.Life (Basel, Switzerland) · 2023Review
- Results of Nailfold Videocapillaroscopy in Patients with Pseudoexfoliative Glaucoma.Life (Basel, Switzerland) · 2023Article
- Prediagnostic Plasma Metabolomics and the Risk of Exfoliation Glaucoma.Investigative ophthalmology & visual science · 2022Article
- Review
- Relationship between homocysteine levels, anterior chamber depth, and pseudoexfoliation glaucoma in patients with pseudoexfoliation.International ophthalmology · 2020Article
- Clinical Features of Pseudoexfoliative Glaucoma in Treated Polish Patients.Clinical ophthalmology (Auckland, N.Z.) · 2020Article
- Nailfold capillary morphology and platelet function in patients with exfoliative glaucoma.PloS one · 2019Article
- Excess homocysteine upregulates the NRF2-antioxidant pathway in retinal Müller glial cells.Experimental eye research · 2019Article
- LOXL1 Polymorphisms: Genetic Biomarkers that Presage Environmental Determinants of Exfoliation Syndrome.Journal of glaucoma · 2018Review
- MTHFR and MTHFD1 gene polymorphisms are not associated with pseudoexfoliation syndrome in South Indian population.International ophthalmology · 2018Article
- Nailfold capillary morphology in exfoliation syndrome.Eye (London, England) · 2017Article
- Association of the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism with primary glaucoma in Saudi population.BMC ophthalmology · 2016Article
- Contribution of the Nurses' Health Study to the Epidemiology of Cataract, Age-Related Macular Degeneration, and Glaucoma.American journal of public health · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe aim of this meta-analysis is to explore the relationship between plasma total homocysteine (tHcy) levels, serum folic acid, vitamin B12 and vitamin B6 levels, methylenetetrahydrofolate reductase (MTHFR) C677T genotype and risk of pseudoexfoliation glaucoma (PEXG).
methodsA systematic search of EMBASE and PubMed of relevant articles was carried out for all published articles. Main outcome measures included the calculation of plasma tHcy levels, serum folic acid, vitamin B12, and vitamin B6 levels mean difference and odds ratios (OR) of MTHFR C677T genotype between cases and controls.
resultsThere were 14 studies for tHcy (485 cases and 456 controls), five studies for folic acid (188 cases and 189 controls), six studies for vitamin B12 (199 cases and 225 controls), three studies for vitamin B6 (128 cases and 130 controls) and eight studies for MTHFR (479 cases and 661 controls). Overall, the mean plasma tHcy levels in cases was 3.38 umol/l (95% confidence intervals (CI): 2.35-4.42) higher than in controls. Serum folic acids, but not vitamin B12 and vitamin B6 levels, was significantly lower in cases than in controls; the weighted mean differences with 95% CI were -1.50 umol/l (-2.53, -0.46), -36.29 umol/l (-81.27, 8.68) and -0.60 umol/l (-2.55, 1.35) respectively. There was no evidence of association between the MTHFR C677T genotype and PEXG (OR = 1.28, 95% CI: 0.85, 1.93).
conclusionsPEXG is associated with elevated plasma tHcy and low serum folic acid levels, but not serum vitamin B12, vitamin B6 levels, and MTHFR C677T genotype.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.