ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2012
Colored perfluorocarbon liquids as novel intraoperative tools.
Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 12 citations in OpenAlex.
- Replacing the vitreous body with hydrogels: Rationale and strategies.Progress in retinal and eye research · 2025Review
- Investigation of the Post-Synthetic Confinement of Fluorous Liquids Inside Mesoporous Silica Nanoparticles.Langmuir : the ACS journal of surfaces and colloids · 2021Article
- [Current importance of heavy fluids as intraoperative aids in vitreoretinal surgery].Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft · 2019Review
- Vitreous substitutes: the present and the future.BioMed research international · 2014Review
- Hyperoxygenation attenuated a murine model of atopic dermatitis through raising skin level of ROS.PloS one · 2014Article
- Subretinal perfluorocarbon liquid for dissection of proliferative vitreoretinopathy.Journal of ophthalmic & vision research · 2012Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPerfluorocarbon liquids (PFCLs) are used as intraoperative tools to stabilize the retina during vitreoretinal surgeries. Their use would be much facilitated if PFCLs were colored and not transparent. We describe the development of a colored PFCL for vitreoretinal surgeries.
methodsPerfluorohexyloctan (F6H8) was colored by adding a blue, biocompatible anthraquinone dye, and then mixed with perfluorodecalin (PFD) or perfluorooctane (PFO) at different volume percentages. The thus-obtained colored PFCLs were incubated with lens, lens capsule, vitreous body, and retina of enucleated porcine eyes for staining purpose and analyzed microscopically. To analyze possible interactions between colored PFCLs and silicone oil, colored PFCLs were exchanged to BSS and silicone oil respectively in enucleated pig eyes.
resultsBy mixing different volume% of colored F6H8 with perfluorodecalin (PFD) or perfluorooctane (PFO), colored PFCLs of different density and staining intensity were obtained. Cornea, lens, lens capsule, vitreous, and retina showed no signs of staining after incubation with colored PFCLs for 10 min. Colored PFCLs were transparent despite intense coloring, thus allowing a clear visibility of the underlying tissue. Immediately after instillation of silicone oil, the colored PFCL bubble was well-defined, and colored PFCL was easily aspirated. After 5 minutes reaction time, considerable diffusion of the dye from the PFCL bubble into the silicone oil was observed.
conclusionsThe staining intensity can be varied according to the volume% of the colored F6H8 phase. Colored PFCL is clearly visible when installed in the vitreous cavity of a pig eye, and can easily be removed. It does not stain the intraocular tissues in pig eyes. Colored PFCL can be exchanged with silicone oil. But a time-dependent diffusion of the dye into the silicone oil was observed in pig eyes, indicating that the contact should be limited.
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