Evidence map›Paper›PMID 22134638›Full record

ReviewApplied microbiology and biotechnology2012

Fungal chitinases: diversity, mechanistic properties and biotechnological potential.

Lukas Hartl, Simone Zach, Verena Seidl-Seiboth

Open access · hybridAbstract readReview
In one paragraph

Review in Applied microbiology and biotechnology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 108 papers.

0numbers the graph read from it
0cells of the map it votes in
108citing papers in PubMed
6.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

108 citing papers in PubMed, 315 citations in OpenAlex.

  1. Review
  2. Genome Assembly and Genomic Characterization ofJournal of fungi (Basel, Switzerland) · 2026
    Article
  3. Journal of fungi (Basel, Switzerland) · 2026
    Article
  4. Article
  5. Article
  6. Functional Study of the ChitinaseJournal of fungi (Basel, Switzerland) · 2026
    Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. The Function of Chitinases CmCH1 and CmCH10 in the Interaction ofInternational journal of molecular sciences · 2025
    Article
  12. Article
  13. Bioactive Compounds and Antioxidant Activity ofMolecules (Basel, Switzerland) · 2025
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Protease and chitinase activity ofFrontiers in microbiology · 2025
    Article
  20. Article

48 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Lukas HartlGene Technology and Applied Biochemistry, Institute of Chemical Engineering, Vienna University of Technology, Gumpendorfer Strasse 1a, 1060, Vienna, Austria.
Simone Zach
Verena Seidl-Seiboth
TU Wien · AT

Funding

Austrian Science Fund FWF P 20559
6 · The paper itself

Abstract

Chitin derivatives, chitosan and substituted chito-oligosaccharides have a wide spectrum of applications ranging from medicine to cosmetics and dietary supplements. With advancing knowledge about the substrate-binding properties of chitinases, enzyme-based production of these biotechnologically relevant sugars from biological resources is becoming increasingly interesting. Fungi have high numbers of glycoside hydrolase family 18 chitinases with different substrate-binding site architectures. As presented in this review, the large diversity of fungal chitinases is an interesting starting point for protein engineering. In this review, recent data about the architecture of the substrate-binding clefts of fungal chitinases, in connection with their hydrolytic and transglycolytic abilities, and the development of chitinase inhibitors are summarized. Furthermore, the biological functions of chitinases, chitin and chitosan utilization by fungi, and the effects of these aspects on biotechnological applications, including protein overexpression and autolysis during industrial processes, are discussed in this review.

Indexed as

Genetic VariationBinding SitesBiotechnologyChitinasesFungiSubstrate SpecificityChitinases

Identifiers

PMID22134638
PMCPMC3257436
OpenAlexW2094800755

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.