ReviewEye (London, England)2012
Association of human papilloma virus with pterygia and ocular-surface squamous neoplasia.
Review in Eye (London, England), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed, 2 syntheses or guidelines pooled it, 104 citations in OpenAlex.
- Epidemiology of ocular surface squamous neoplasia in Africa.Tropical medicine & international health : TM & IH · 2013Pooled it
- HIV and HPV infections and ocular surface squamous neoplasia: systematic review and meta-analysis.British journal of cancer · 2013Pooled it
- Cetuximab combination with cytokine induced killer cells effectively inhibit conjunctival squamous cell carcinoma in vitro.BMC immunology · 2026Article
- Ocular Findings in Women with Cervical HPV Positivity and Cervical Dysplasia Undergoing Loop Electrosurgical Excision Procedure: A Prospective Cross-Sectional Study.Medicina (Kaunas, Lithuania) · 2026Observational
- Potential Role ofInternational journal of molecular sciences · 2025Article
- Update in the Diagnosis and Management of Ocular Surface Squamous Neoplasia (OSSN).Journal of clinical medicine · 2025Review
- Infectious etiologies of conjunctival tumors.Expert review of ophthalmology · 2025Article
- Unusual presentation of ocular surface squamous neoplasia in a young healthy patient: A case report.European journal of ophthalmology · 2024Article
- Novel automated non-invasive detection of ocular surface squamous neoplasia using artificial intelligence.World journal of methodology · 2024Review
- Prevalence of co-existent neoplasia in clinically diagnosed pterygia in a UK population.Eye (London, England) · 2023Article
- High-risk human papillomavirus-associated corneal/conjunctival intraepithelial neoplasia in a young patient.American journal of ophthalmology case reports · 2023Article
- The role of HPV in the etiopathogenesis of pterygium and the relationship with recurrence.International ophthalmology · 2023Article
- The Management of Ocular Surface Squamous Neoplasia (OSSN).International journal of molecular sciences · 2022Review
- Detection of Human Papillomavirus in Squamous Lesions of the Conjunctiva Using RNA and DNA In-Situ Hybridization.International journal of molecular sciences · 2022Article
- Ocular surface squamous neoplasia in Northern Thailand: a 16-year review.BMC ophthalmology · 2022Article
- Role of oncogenic viruses in the development ocular surface squamous neoplasia.International ophthalmology · 2021Article
- Identification of microbial agents in tissue specimens of ocular and periocular sarcoidosis using a metagenomics approach.F1000Research · 2021Article
- Relative gene expression analysis of human pterygium tissues and UV radiation-evoked gene expression patterns in corneal and conjunctival cells.Experimental eye research · 2020Article
- Clinical demographics of pterygium excision and prevalence of conjunctival intraepithelial neoplasia: a 15-year review.International ophthalmology · 2020Article
- p16 Expression Correlates with Invasive Ocular Surface Squamous Neoplasms in HIV-Infected Mozambicans.Ocular oncology and pathology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There are more microorganisms that colonize the human body than resident cells; some are commensal whereas others are pathogenic. Pathogenic microorganisms are sensed by the innate or adaptive immune system, an immune response is initiated, and the infection is often cleared. Some microorganisms have developed strategies to evade immune defenses, ensuring their long-term survival with potentially devastating consequences for the host. Approximately 18% of all cancers can be attributed to infective agents; the most common being Helicobacter pylori, Human papilloma virus (HPV) and Hepatitis B and C virus in causing stomach, cervical and liver carcinoma, respectively. This review focuses on whether HPV infection is necessary for initiating pterygia, a common benign condition and ocular-surface squamous neoplasia (OSSN), a rare disease with metastatic potential. The search engine PubMed was used to identify articles from the literature related to HPV and pterygium or conjunctival neoplasia. From 34 investigations that studied HPV in pterygia and OSSN, a prevalence rate of 18.6% (136/731) and 33.8% (144/426), respectively, was recorded. The variation in HPV prevalence (0-100%) for both disease groups may have arisen from study-design faults and the techniques used to identify the virus. Overall, the data suggest that HPV is not necessary for initiating either condition but may be a co-factor in susceptible hosts. Currently, over 60 million people worldwide have been immunized with HPV vaccines, but any effect on pterygium and OSSN development may not be known for some time as these lesions can evolve over decades or occur in older individuals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.