ArticleJournal of computational neuroscience2012
Co-variation of ionic conductances supports phase maintenance in stomatogastric neurons.
Article in Journal of computational neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- When can neuronal activity-dependent homeostatic plasticity maintain circuit-level properties?Journal of computational neuroscience · 2026Article
- Homeostatic regulation of neuronal function: importance of degeneracy and pleiotropy.Frontiers in cellular neuroscience · 2023Review
- Loss or gain of function? Effects of ion channel mutations on neuronal firing depend on the neuron type.Frontiers in neurology · 2023Article
- Pareto optimality, economy-effectiveness trade-offs and ion channel degeneracy: improving population modelling for single neurons.Open biology · 2022Review
- Article
- Integration of Within-Cell Experimental Data With Multi-Compartmental Modeling Predicts H-Channel Densities and Distributions in Hippocampal OLM Cells.Frontiers in cellular neuroscience · 2020Article
- The transient potassium outward current has different roles in modulating the pyloric and gastric mill rhythms in the stomatogastric ganglion.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2017Article
- Homeostatic plasticity of excitability in crustacean central pattern generator networks.Current opinion in neurobiology · 2017Review
- The complexity of small circuits: the stomatogastric nervous system.Current opinion in neurobiology · 2016Review
- Feedback control of variability in the cycle period of a central pattern generator.Journal of neurophysiology · 2015Article
- Differential effects of conductances on the phase resetting curve of a bursting neuronal oscillator.Journal of computational neuroscience · 2015Article
- Robust circuit rhythms in small circuits arise from variable circuit components and mechanisms.Current opinion in neurobiology · 2015Review
- Monoaminergic tone supports conductance correlations and stabilizes activity features in pattern generating neurons of the lobster, Panulirus interruptus.Frontiers in neural circuits · 2015Article
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- Article
- Phase maintenance in a rhythmic motor pattern during temperature changes in vivo.Journal of neurophysiology · 2014Article
- The integrative role of the sigh in psychology, physiology, pathology, and neurobiology.Progress in brain research · 2014Review
- A codimension-2 bifurcation controlling endogenous bursting activity and pulse-triggered responses of a neuron model.PloS one · 2014Article
- Correlated conductance parameters in leech heart motor neurons contribute to motor pattern formation.PloS one · 2013Article
- Activation of high and low affinity dopamine receptors generates a closed loop that maintains a conductance ratio and its activity correlate.Frontiers in neural circuits · 2013Article
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3 authors.
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Abstract
Neuronal networks produce reliable functional output throughout the lifespan of an animal despite ceaseless molecular turnover and a constantly changing environment. Central pattern generators, such as those of the crustacean stomatogastric ganglion (STG), are able to robustly maintain their functionality over a wide range of burst periods. Previous experimental work involving extracellular recordings of the pyloric pattern of the STG has demonstrated that as the burst period varies, the inter-neuronal delays are altered proportionally, resulting in burst phases that are roughly invariant. The question whether spike delays within bursts are also proportional to pyloric period has not been explored in detail. The mechanism by which the pyloric neurons accomplish phase maintenance is currently not obvious. Previous studies suggest that the co-regulation of certain ion channel properties may play a role in governing neuronal activity. Here, we observed in long-term recordings of the pyloric rhythm that spike delays can vary proportionally with burst period, so that spike phase is maintained. We then used a conductance-based model neuron to determine whether co-varying ionic membrane conductances results in neural output that emulates the experimentally observed phenomenon of spike phase maintenance. Next, we utilized a model neuron database to determine whether conductance correlations exist in model neuron populations with highly maintained spike phases. We found that co-varying certain conductances, including the sodium and transient calcium conductance pair, causes the model neuron to maintain a specific spike phase pattern. Results indicate a possible relationship between conductance co-regulation and phase maintenance in STG neurons.
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