ArticleJournal of natural medicines2012
Pharmacological explanation for the medicinal use of Juniperus excelsa in hyperactive gastrointestinal and respiratory disorders.
Article in Journal of natural medicines, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Plant-based therapeutics for leishmaniasis: A systematic review emphasizing human studies and clinical trial evidence.PLoS neglected tropical diseases · 2026Pooled it
- Antioxidant and hepatoprotective activities ofResearch in pharmaceutical sciences · 2024Article
- Biosynthesis of silver nano-drug using3 Biotech · 2021Article
- Phytotoxicity and antifungal properties of the essential oil from thePhysiology and molecular biology of plants : an international journal of functional plant biology · 2020Article
- Evaluation of bronchodialatory and antimicrobial activities ofSaudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2020Article
- Use of Natural Products in Asthma Treatment.Evidence-based complementary and alternative medicine : eCAM · 2020Review
- Hydrodistillation Extraction Kinetics Regression Models for Essential Oil Yield and Composition inMolecules (Basel, Switzerland) · 2019Article
- The Current Status of the Pharmaceutical Potential ofMedicines (Basel, Switzerland) · 2018Review
- Antispasmodic, bronchodilator, vasorelaxant and cardiosuppressant effects of Buxus papillosa.BMC complementary and alternative medicine · 2017Article
- Pharmacological Basis for the Medicinal Use of Lepidium sativum in Airways Disorders.Evidence-based complementary and alternative medicine : eCAM · 2012Article
- Chemical composition and antimicrobial activity of essential oils of Juniperus excelsa Bieb. (Cupressaceae) grown in R. Macedonia.Pharmacognosy researchArticle
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Crude extract of Juniperus excelsa (JeExt), which tested positive for the presence of anthraquinone, flavonoids, saponins, sterols, terpenes and tannin, exhibited a protective effect against castor oil-induced diarrhoea in mice at 100-1000 mg/kg. In rabbit jejunum preparations, JeExt (0.01-1.0 mg/mL) caused relaxation of spontaneous and K(+) (80 mM)-induced contractions at similar concentrations to papaverine, whereas verapamil was relatively more potent against K(+). JeExt (0.03-0.3 mg/mL) shifted Ca(2+) concentration-response curves to the right, like papaverine or verapamil. JeExt (0.003-0.01 mg/mL) caused a leftward shift of isoprenaline-induced inhibitory concentration-response curves, similar to papaverine. JeExt (1.0-30 mg/kg) caused suppression of carbachol (CCh, 100 μg/kg)-induced increase in inspiratory pressure of anaesthetized rats. In guinea-pig trachea, JeExt (0.001-3.0 mg/mL) relaxed CCh (1 μM)- and high K(+)-induced contractions and shifted isoprenaline-induced inhibitory curves to the left. This study suggests that Juniperus excelsa possibly exhibits a combination of Ca(2+) antagonist and phosphodiesterase inhibitory effects, which provides a pharmacological basis for its traditional use in disorders of gut and airways hyperactivity, such as diarrhoea, colic and asthma.
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Registered trials
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