ReviewKnee surgery, sports traumatology, arthroscopy : official journal of the ESSKA2012
Local anaesthetics and chondrotoxicty: What is the evidence?
Review in Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed.
- Adverse events associated with local anaesthetic use in musculoskeletal injection therapy: a scoping review.BMJ open sport & exercise medicine · 2026Article
- Lidocaine Shows Significant Antimicrobial Effects AgainstBiomedicines · 2025Article
- Computational Metrics Can Provide Quantitative Values to Characterize Arthroscopic Field of View.Arthroscopy, sports medicine, and rehabilitation · 2022Article
- Neurotropin protects rotator cuff tendon cells from lidocaine-induced cell death.Clinics in shoulder and elbow · 2021Article
- Toxicity of tranexamic acid (TXA) to intra-articular tissue in orthopaedic surgery: a scoping review.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2021Article
- Comparison ofFrontiers in pain research (Lausanne, Switzerland) · 2021Review
- How does intraarticular dexmedetomidine injection effect articular cartilage and synovium? An animal study.BMC anesthesiology · 2020Article
- Local Anesthetics' Toxicity toward Human Cultured Chondrocytes: A Comparative Study between Lidocaine, Bupivacaine, and Ropivacaine.Cartilage · 2019Article
- Protective effects of platelet-rich plasma against lidocaine cytotoxicity on canine articular chondrocytes.Acta veterinaria Scandinavica · 2018Article
- Injection of tennis elbow: Hit and miss? A cadaveric study of injection accuracy.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2017Article
- Article
- In vitro chondrocyte toxicity following long-term, high-dose exposure to Gd-DTPA and a novel cartilage-targeted MR contrast agent.Skeletal radiology · 2017Article
- In Vitro Toxicity of Local Anesthetics and Corticosteroids on Chondrocyte and Synoviocyte Viability and Metabolism.Cartilage · 2015Article
- [Osteoarthritis: what internists should know].Der Internist · 2015Review
- [Pharmacological therapy of arthrosis].Zeitschrift fur Rheumatologie · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeRecent reports have suggested that local anaesthetic agents have a toxic effect on articular chondrocytes. This is despite the widespread intra-articular use of local anaesthetic agents following arthroscopic procedures for a number of years.
methodsWe have reviewed the available basic science literature focusing on the studies assessing the effect of exposing articular chondrocytes to local anaesthetic agents. We attempt to highlight the key findings and, where possible, extrapolate the laboratory findings to the operating theatre.
resultsBasic science reports are analysed according to their setting of either in vitro, ex vivo or in vivo and according to cell line. A majority of work to date has been done using in vitro models. Only a small number of in vivo models using animal cell lines have been used and the best of these have conflicting results with regard lasting toxicity secondary to local anaesthetic exposure.
conclusionsNumerous reports suggest a toxic effect of local anaesthetic agents on articular chondrocytes, however, further work is warranted to establish the precise mechanism of toxicity and whether or not single bolus administration results in long-term deleterious outcomes. Determining the ideal in vitro model will help in extrapolating laboratory data to the operating theatre.
Indexed as
Identifiers
22134409What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.