ReviewCurrent opinion in HIV and AIDS2012
Systems biology of natural simian immunodeficiency virus infections.
Review in Current opinion in HIV and AIDS, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 27 citations in OpenAlex.
- Pro-inflammatory feedback loops define immune responses to pathogenic Lentivirus infection.Genome medicine · 2024Article
- The CD8Microbiology and molecular biology reviews : MMBR · 2021Review
- Review
- Article
- Time-Course Gene Set Analysis for Longitudinal Gene Expression Data.PLoS computational biology · 2015Article
- Systems-level analysis of innate immunity.Annual review of immunology · 2014Review
- Insights from natural host-parasite interactions: the Drosophila model.Developmental and comparative immunology · 2014Review
- Loss of a tyrosine-dependent trafficking motif in the simian immunodeficiency virus envelope cytoplasmic tail spares mucosal CD4 cells but does not prevent disease progression.Journal of virology · 2013Article
- Systems biology of the vervet monkey.ILAR journal · 2013Review
- Critical dynamics in host-pathogen systems.Current topics in microbiology and immunology · 2013Review
- Distinct evolutionary pressures underlie diversity in simian immunodeficiency virus and human immunodeficiency virus lineages.Journal of virology · 2012Article
- Expression sequence tag library derived from peripheral blood mononuclear cells of the chlorocebus sabaeus.BMC genomics · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
purpose of reviewA key factor driving AIDS-associated immunopathogenesis is chronic immune activation. Simian immunodeficiency virus (SIV) infection of African natural host species leads to high viremia, but low immune activation and absence of disease. Considerable progress in our understanding of pathological immune activation has come from comparative studies of SIV infection in pathogenic Asian macaque species and natural hosts. The focus of this review is to highlight recent work on the natural host model using high-throughput genomics. RECENT
findingsSeveral groups have independently conducted microarray gene expression profiling comparing in-vivo SIV infection in natural and non-natural hosts. A consistent finding between these studies is that both pathogenic SIV infection of macaques and nonpathogenic infections of natural hosts have strong induction of interferon-stimulated genes (ISGs) early on, but a key difference was that natural hosts down-modulated the interferon response rapidly after acute infection. The development of new genome-based resources for further study of the natural host model is discussed. SUMMARY: Initial efforts using high-throughput biology to study SIV infection of natural hosts have effectively identified the ability of natural hosts to resolve interferon responses and immune activation. Further application of 'omic-based technologies coupled with integrative systems-based analysis should continue to yield progress.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.