ArticleCell cycle (Georgetown, Tex.)2011
Unmasking a temperature-dependent effect of the P. anserina i-AAA protease on aging and development.
Article in Cell cycle (Georgetown, Tex.), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 33 citations in OpenAlex.
- Mitochondrial quality control in health and disease: mechanisms and therapeutic targets.Signal transduction and targeted therapy · 2026Review
- What are the 100 most cited fungal genera?Studies in mycology · 2024Article
- Aging ofCells · 2021Article
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- A Network of Pathways Controlling Cellular Homeostasis Affects the Onset of Senescence inJournal of fungi (Basel, Switzerland) · 2021Review
- Impaired FCells · 2021Article
- Simultaneous Ablation of the Catalytic AMPK α-Subunit SNF1 and Mitochondrial Matrix Protease CLPP Results in Pronounced Lifespan Extension.Frontiers in cell and developmental biology · 2021Article
- Autophagy compensates impaired energy metabolism in CLPXP-deficient Podospora anserina strains and extends healthspan.Aging cell · 2017Article
- Stress-dependent opposing roles for mitophagy in aging of the ascomycete Podospora anserina.Autophagy · 2017Article
- RCF1-dependent respiratory supercomplexes are integral for lifespan-maintenance in a fungal ageing model.Scientific reports · 2015Article
- Control of mitochondrial integrity in ageing and disease.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2014Review
- Effect of paraquat-induced oxidative stress on gene expression and aging of the filamentous ascomyceteMicrobial cell (Graz, Austria) · 2014Article
- Identification of autophagy as a longevity-assurance mechanism in the aging model Podospora anserina.Autophagy · 2014Article
- Inheritance of the fittest mitochondria in yeast.Trends in cell biology · 2014Review
- Human CLPP reverts the longevity phenotype of a fungal ClpP deletion strain.Nature communications · 2013Article
- Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Different molecular pathways involved in maintaining mitochondrial function are of fundamental importance to control cellular homeostasis. Mitochondrial i-AAA protease is part of such a surveillance system and PaIAP is the putative ortholog in the fungal aging model Podospora anserina. Here we investigated the role of PaIAP in aging and development. Deletion of the gene encoding PaIAP resulted in a specific phenotype. When incubated at 27°C, spore germination and fruiting body formation are not different from that of the corresponding wild-type strain. Unexpectedly, the lifespan of the deletion strain is strongly increased. In contrast, cultivation at an elevated temperature of 37°C leads to impairments in spore germination and fruiting body formation, and to a reduced lifespan. The higher PaIAP abundance in wild-type strains of the fungus grown at elevated temperature and the phenotype of the deletion strain unmasks a temperature-related role of the protein. The protease appears to be part of a molecular system that has evolved to allow survival under changing temperatures as they characteristically occur in nature.
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