ReviewThe Journal of clinical investigation2011
Syphilis: using modern approaches to understand an old disease.
Review in The Journal of clinical investigation, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 96 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
96 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Prevalence and associated factors of syphilis among female sex workers in East Africa: a systematic review and meta-analysis.Frontiers in public health · 2025Pooled it
- 2023 Korean sexually transmitted infections guidelines for non-gonococcal bacterial infection (chlamydia, syphilis, etc.) by the Korean Association of Urogenital Tract Infection and Inflammation.Investigative and clinical urology · 2024Guideline
- Seroprevalence of Syphilis Among Pregnant Women on Antenatal Care Service at Wereda 04 Health Center in Kolfe Keraniyo Subcity, Addis Ababa, Ethiopia: A Cross-Sectional Study.Health science reports · 2026Article
- Syphilis epidemiology in Jordan: prevalence, incidence, and seroreversion from 15 years of laboratory-based data.Scientific reports · 2026Observational
- Article
- Article
- Comparative performance of the traditional and reverse diagnostic algorithms for syphilis in pregnancy.Pregnancy (Hoboken, N.J.) · 2026Article
- Canadian Public Health Laboratory Network National Syphilis In-Laboratory Serological Testing Recommendations.Journal of the Association of Medical Microbiology and Infectious Disease Canada = Journal officiel de l'Association pour la microbiologie medicale et l'infectiologie Canada · 2025Review
- The Return of an Old Foe: Syphilis Among Women.Clinical obstetrics and gynecology · 2025Review
- Dietary Galacto-Oligosaccharides Enhance Growth Performance and Modulate Gut Microbiota in Weaned Piglets: A Sustainable Alternative to Antibiotics.Animals : an open access journal from MDPI · 2025Article
- Dual Immunization with Lipoprotein Tp0663 and Flagellin FlaB3 Offers Augmented Protection againstACS omega · 2025Article
- Treponema denticola major surface protein (Msp): a key player in periodontal pathogenicity and immune evasion.Archives of microbiology · 2025Review
- Seroprevalence of hepatitis A virus, hepatitis B virus, hepatitis C virus, and syphilis among human immunodeficiency virus-infected people at a university hospital, Turkey.Archives of medical science : AMS · 2025Article
- The Significance of the Cell-Mediated Host Immune Response in Syphilis.Microorganisms · 2024Review
- Prevalence of syphilis infection among migrant workers in Qatar: a nationwide cross-sectional survey.BMJ open · 2024Article
- Syphilis infection prevalence in the Middle East and North Africa: a systematic review and meta-analysis.EClinicalMedicine · 2024Article
- Ocular vs neurosyphilis. are they the same? A guide to investigation and management.Eye (London, England) · 2024Review
- Prevalence and Predictors of Oral Treponema pallidum Detection by Quantitative Polymerase Chain Reaction in Early Syphilis.The Journal of infectious diseases · 2024Article
- Article
- Review
36 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Syphilis is a fascinating and perplexing infection, with protean clinical manifestations and both diagnostic and management ambiguities. Treponema pallidum subsp. pallidum, the agent of syphilis, is challenging to study in part because it cannot be cultured or genetically manipulated. Here, we review recent progress in the application of modern molecular techniques to understanding the biological basis of this multistage disease and to the development of new tools for diagnosis, for predicting efficacy of treatment with alternative antibiotics, and for studying the transmission of infection through population networks.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.