ReviewThe Journal of allergy and clinical immunology2011
Asthma exacerbations: origin, effect, and prevention.
Review in The Journal of allergy and clinical immunology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 143 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Late Phase Administration Anakinra as a Rescue Treatment for Inhaled Allergen Challenge-Induced Airway Inflammation
Early Phase Administration of Anakinra as a Rescue Treatment for Inhaled Allergen Challenge-Induced Airway Inflammation
Who cites it
143 citing papers in PubMed, 7 syntheses or guidelines pooled it.
- Pooled it
- Management of asthma exacerbations in the paediatric population: a systematic review.European respiratory review : an official journal of the European Respiratory Society · 2021Pooled it
- Impact of non-drug therapies on asthma control: A systematic review of the literature.The European journal of general practice · 2019Pooled it
- Antibiotics for exacerbations of asthma.The Cochrane database of systematic reviews · 2018Pooled it
- Pooled it
- Comparative effectiveness of long term drug treatment strategies to prevent asthma exacerbations: network meta-analysis.BMJ (Clinical research ed.) · 2014Pooled it
- Associations between environmental exposures and asthma control and exacerbations in young children: a systematic review.BMJ open · 2014Pooled it
- Asthma hospitalisations and heat exposure in England: a case-crossover study during 2002-2019.Thorax · 2023Trial
- Bronchial mucosal IFN-α/β and pattern recognition receptor expression in patients with experimental rhinovirus-induced asthma exacerbations.The Journal of allergy and clinical immunology · 2019Trial
- Preseasonal treatment with either omalizumab or an inhaled corticosteroid boost to prevent fall asthma exacerbations.The Journal of allergy and clinical immunology · 2015Trial
- Increased frequency of dual-positive TH2/TH17 cells in bronchoalveolar lavage fluid characterizes a population of patients with severe asthma.The Journal of allergy and clinical immunology · 2014Trial
- Transient Oral Corticosteroid Use and Acute Upper Gastrointestinal Bleeding in Mild-to-Moderate Asthma: A Case-Crossover Study.Drug safety · 2026Article
- Climate change, environmental exposures, and pediatric asthma exacerbations: air pollution, temperature, and relative humidity.Pediatric research · 2026Review
- Misconceptions of Traits to Predict Response to Inhaled Corticosteroid and Bronchodilator Therapies in Asthma: A Narrative Review.Pulmonary therapy · 2026Review
- Immune Training of the Interleukin 6 Gene in Airway Epithelial Cells is Central to Asthma Exacerbations.Allergy · 2026Article
- The Human Respiratory Virome in Health and Disease: Interactions, Dysbiosis, and Methodological Challenges.Advanced genetics (Hoboken, N.J.) · 2025Review
- Age-Dependent Risk of Bronchial Asthma Exacerbation in Respiratory Syncytial Virus Co-infection.Lung · 2025Article
- CompEx Asthma: is it time for a change in clinical trials?The European respiratory journal · 2025Article
- The association between vitamin D intake and the prevalence and mortality of asthma in the US adults.Nutrition journal · 2025Article
- The Impact of the Quality of Care for Adults with Acute Asthma in the Emergency Department of a Tertiary Hospital: A 1-Year Follow-Up Study.Clinics and practice · 2025Article
83 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Asthma is the most common chronic respiratory disease, affecting up to 10% of adults and 30% of children in the Western world. Despite advances in asthma management, acute exacerbations continue to occur and impose considerable morbidity on patients and constitute a major burden on health care resources. Respiratory tract viruses have emerged as the most frequent triggers for exacerbations in both children and adults; however, the mechanisms underlying these remain poorly understood. More recently, it has become increasingly clear that interactions might exist between viruses and other triggers, increasing the likelihood of an exacerbation. In this article we begin with an overview of the health, economic, and social burden that exacerbations of asthma carry with them. This is followed by a review of the pathogenesis of asthma exacerbations, highlighting the various triggers responsible and multiple interactions that exist between them. The final section first addresses what preventative measures are currently available for asthma exacerbations and subsequently examines which of the new treatments in development might lessen the burden of exacerbations in the future.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.