ArticleJournal of translational medicine2011
Astrocyte elevated gene-1 (AEG-1) is a marker for aggressive salivary gland carcinoma.
Article in Journal of translational medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 33 citations in OpenAlex.
- Metadherin: A pivotal oncogene and therapeutic target in head and neck cancer - a systematic review.The Japanese dental science review · 2026Review
- Ribosome Biogenesis Regulator 1 Homolog (RRS1) Promotes Cisplatin Resistance by Regulating AEG-1 Abundance in Breast Cancer Cells.Molecules (Basel, Switzerland) · 2023Article
- The Scope of Astrocyte Elevated Gene-1/Metadherin (AEG-1/MTDH) in Cancer Clinicopathology: A Review.Genes · 2021Review
- Observational
- Metadherin: A Therapeutic Target in Multiple Cancers.Frontiers in oncology · 2019Review
- Astrocyte Elevated Gene 1 (AEG-1): A Promising Candidate for Molecular Targeted Therapy in Oral Squamous Cell CarcinomasAsian Pacific journal of cancer prevention : APJCP · 2017Article
- The expression of AEG-1 and Cyclin D1 in human bladder urothelial carcinoma and their clinicopathological significance.International journal of clinical and experimental medicine · 2015Article
- MicroRNA-542-3p suppresses cell growth of gastric cancer cells via targeting oncogene astrocyte-elevated gene-1.Medical oncology (Northwood, London, England) · 2015Article
- The role of MTDH/AEG-1 in the progression of cancer.International journal of clinical and experimental medicine · 2015Review
- AEG-1 expression correlates with CD133 and PPP6c levels in human glioma tissues.Journal of biomedical research · 2014Article
- Metadherin expression and lung relapse in patients with colorectal carcinoma.Clinical & experimental metastasis · 2014Article
- Astrocyte elevated gene-1 is a novel modulator of HIV-1-associated neuroinflammation via regulation of nuclear factor-κB signaling and excitatory amino acid transporter-2 repression.The Journal of biological chemistry · 2014Article
- AEG-1 is associated with tumor progression in nonmuscle-invasive bladder cancer.Medical oncology (Northwood, London, England) · 2014Article
- Regulation of the localisation and function of the oncogene LYRIC/AEG-1 by ubiquitination at K486 and K491.Molecular oncology · 2014Article
- High expression of astrocyte elevated gene-1 (AEG-1) is associated with progression of cervical intraepithelial neoplasia and unfavorable prognosis in cervical cancer.World journal of surgical oncology · 2013Article
- Astrocyte elevated gene-1 regulates osteosarcoma cell invasion and chemoresistance via endothelin-1/endothelin A receptor signaling.Oncology letters · 2013Article
- AEG-1/MTDH/LYRIC: clinical significance.Advances in cancer research · 2013Review
- AEG-1/MTDH/LYRIC: signaling pathways, downstream genes, interacting proteins, and regulation of tumor angiogenesis.Advances in cancer research · 2013Article
- AEG-1/MTDH/LYRIC, the beginning: initial cloning, structure, expression profile, and regulation of expression.Advances in cancer research · 2013Review
- Clinical implications of AEG-1 in liver metastasis of colorectal cancer.Medical oncology (Northwood, London, England) · 2012Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAstrocyte elevated gene-1 (AEG-1) is associated with tumorigenesis and progression in diverse human cancers. The present study was aimed to investigate the clinical and prognostic significance of AEG-1 in salivary gland carcinomas (SGC).
methodsReal-time PCR and western blot analyses were employed to examine AEG-1 expression in two normal salivary gland tissues, eight SGC tissues of various clinical stages, and five pairs of primary SGC and adjacent salivary gland tissues from the same patient. Immunohistochemistry (IHC) was performed to examine AEG-1 protein expression in paraffin-embedded tissues from 141 SGC patients. Statistical analyses was applies to evaluate the diagnostic value and associations of AEG-1 expression with clinical parameters.
resultsAEG-1 expression was evidently up-regulated in SGC tissues compared with that in the normal salivary gland tissues and in matched adjacent salivary gland tissues. AEG-1 protein level was positively correlated with clinical stage (P < 0.001), T classification (P = 0.008), N classification (P = 0.008) and M classifications (P = 0.006). Patients with higher AEG-1 expression had shorter overall survival time, whereas those with lower tumor AEG-1 expression had longer survival time.
conclusionsOur results suggest that AEG-1 expression is associated with SGC progression and may represent a novel and valuable predictor for prognostic evaluation of SGC patients.
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