ArticleStem cells and development2012
Tip110 maintains expression of pluripotent factors in and pluripotency of human embryonic stem cells.
Article in Stem cells and development, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 27 citations in OpenAlex.
- A bioinformatics pipeline for the design of a SART3-targeted cancer vaccine with enhanced immunogenicity.Genomics & informatics · 2026Article
- Article
- Article
- Variants in SART3 cause a spliceosomopathy characterised by failure of testis development and neuronal defects.Nature communications · 2023Article
- The spliceosome factor sart3 regulates hematopoietic stem/progenitor cell development in zebrafish through the p53 pathway.Cell death & disease · 2021Article
- The RNA-binding protein SART3 promotes miR-34a biogenesis and GThe Journal of biological chemistry · 2019Article
- miRNA regulation of Tip110 expression and self-renewal and differentiation of human CD34+ hematopoietic cells.Oncotarget · 2018Article
- Stress granule-associated protein G3BP2 regulates breast tumor initiation.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- A functional genomics screen identifies an Importin-α homolog as a regulator of stem cell function and tissue patterning during planarian regeneration.BMC genomics · 2015Article
- MicroRNA-124 Targets Tip110 Expression and Regulates Hematopoiesis.Stem cells and development · 2015Article
- Tip110 Regulates the Cross Talk between p53 and Hypoxia-Inducible Factor 1α under Hypoxia and Promotes Survival of Cancer Cells.Molecular and cellular biology · 2015Article
- Regulation of neuronal survival and morphology by the E3 ubiquitin ligase RNF157.Cell death and differentiation · 2015Article
- Tip110 binding to U6 small nuclear RNA and its participation in pre-mRNA splicing.Cell & bioscience · 2015Article
- RNA-binding proteins in pluripotency, differentiation, and reprogramming.Frontiers in biology · 2014Article
- Tip110 protein binds to unphosphorylated RNA polymerase II and promotes its phosphorylation and HIV-1 long terminal repeat transcription.The Journal of biological chemistry · 2014Article
- Tip110 interacts with YB-1 and regulates each other's function.BMC molecular biology · 2013Article
- C-MYC controlled TIP110 protein expression regulates OCT4 mRNA splicing in human embryonic stem cells.Stem cells and development · 2013Article
- Enhancing engraftment of cord blood cells via insight into the biology of stem/progenitor cell function.Annals of the New York Academy of Sciences · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
HIV-1 Tat-interacting protein of 110 kDa [Tip110; p110(nrb)/SART3/p110] is an RNA binding nuclear protein implicated in regulation of HIV-1 gene and host gene transcription, pre-mRNA splicing, and cancer immunology. Recently, we demonstrated a role for Tip110 in regulation of hematopoiesis. Here, we show that TIP110 is also expressed in human embryonic stem cells (hESCs) and expression was decreased with differentiation of these ESCs. TIP110 was found, through up- and down-modulation of expression of Tip110, to be important in maintaining pluripotent factor (NANOG, OCT4, and SOX2) expression in and pluripotency of hESCs, although the mechanisms involved and whether the Tip110 effects are direct remain to be determined.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.