ArticleJournal of aging research2011
Neuroinflammation and cerebrovascular disease in old age: a translational medicine perspective.
Article in Journal of aging research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
21 citing papers in PubMed, 263 citations in OpenAlex.
- Aging, vascular dysfunction, and the blood-brain barrier: unveiling the pathophysiology of stroke in older adults.Biogerontology · 2025Review
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- HIV Promotes Neurocognitive Impairment by Damaging the Hippocampal Microvessels.Molecular neurobiology · 2022Article
- Molecular Mechanisms of Neuroimmune Crosstalk in the Pathogenesis of Stroke.International journal of molecular sciences · 2021Review
- Cell senescence in neuropathology: A focus on neurodegeneration and tumours.Neuropathology and applied neurobiology · 2021Review
- Efficacy and safety of vascular intervention combined with intravenous thrombolysis in treatment of acute intracranial arterial occlusion.Experimental and therapeutic medicine · 2020Article
- Article
- Task-related changes in degree centrality and local coherence of the posterior cingulate cortex after major cardiac surgery in older adults.Human brain mapping · 2018Article
- Dysfunction of Cerebrovascular Endothelial Cells: Prelude to Vascular Dementia.Frontiers in aging neuroscience · 2018Review
- Dysfunction of the neurovascular unit in ischemic stroke and neurodegenerative diseases: An aging effect.Ageing research reviews · 2017Review
- Cerebral ischemic damage in diabetes: an inflammatory perspective.Journal of neuroinflammation · 2017Review
- Notch signaling in cerebrovascular diseases (Review).Molecular medicine reports · 2016Review
- Neuroprotective effect of paeoniflorin on HExperimental and therapeutic medicine · 2015Article
- Effects of high-fat diet on neuronal damage, gliosis, inflammatory process and oxidative stress in the hippocampus induced by transient cerebral ischemia.Neurochemical research · 2014Article
- Alzheimer's disease and immunotherapy.Aging and disease · 2013Article
- Article
- Effects of different doses of doxepin on passive avoidance learning in rats.Advanced biomedical research · 2013Article
- Triggers and effectors of oxidative stress at blood-brain barrier level: relevance for brain ageing and neurodegeneration.Oxidative medicine and cellular longevity · 2013Review
- Age and the metabolic syndrome as risk factors for ischemic stroke: improving preclinical models of ischemic stroke.The Yale journal of biology and medicine · 2012Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The incidence of cerebrovascular disease is highest in the elderly population. However, the pathophysiological mechanisms of brain response to cerebral ischemia in old age are currently poorly understood. Ischemic changes in the commonly used young animal stroke models do not reflect the molecular changes associated with the aged brain. Neuroinflammation and oxidative stress are important pathogenic processes occurring during the acute phase of cerebral ischemia. Free radical generation is also implicated in the aging process, and the combination of these effects in elderly stroke patients could explain the higher risk of morbidity and mortality. A better understanding of stroke pathophysiology in the elderly patient would assist in the development of new therapeutic strategies for this vulnerable age group. With the increasing use of reperfusion therapies, inflammatory pathways and oxidative stress remain attractive therapeutic targets for the development of adjuvant neuroprotective agents. This paper will discuss these molecular aspects of acute stroke and senescence from a bench-to-bedside research perspective.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.