ArticleJournal of nutrition and metabolism2011
T2DM: Why Epigenetics?
Article in Journal of nutrition and metabolism, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed.
- Electroacupuncture alleviates type 2 diabetes mellitus by promoting plasma-derived exosomal circular RNA of enhancer of zeste homolog 1 expression.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2025Article
- Comprehensive treatment of diabetic endothelial dysfunction based on pathophysiological mechanism.Frontiers in medicine · 2025Review
- DNA Methylation and Type 2 Diabetes: Novel Biomarkers for Risk Assessment?International journal of molecular sciences · 2021Review
- Phytochemicals as Potential Epidrugs in Type 2 Diabetes Mellitus.Frontiers in endocrinology · 2021Review
- Improved control of non-communicable diseases (NCDs) requires an additional advanced concept for public health - a perspective from a middle-income country.F1000Research · 2019Article
- Public health research needs for molecular epidemiology and to emphasize homeostasis - could the omnipotent endopeptidase inhibitor α-2-macroglobulin be a meaningful biomarker?F1000Research · 2019Article
- Article
- Relationship between homeostasis model assessment of insulin resistance and beta cell function and serum 25-hydroxyvitamin D in non-diabetic Korean adults.Journal of clinical biochemistry and nutrition · 2016Article
- Persistent Chromatin Modifications Induced by High Fat Diet.The Journal of biological chemistry · 2016Article
- The early life origin theory in the development of cardiovascular disease and type 2 diabetes.Molecular biology reports · 2015Review
- Type 2 diabetes mellitus in relation to global LINE-1 DNA methylation in peripheral blood: a cohort study.Epigenetics · 2014Article
- You are what you eat, or are you? The challenges of translating high-fat-fed rodents to human obesity and diabetes.Nutrition & diabetes · 2014Review
- Insulin downregulates the expression of the Ca2+-activated nonselective cation channel TRPM5 in pancreatic islets from leptin-deficient mouse models.Pflugers Archiv : European journal of physiology · 2014Article
- Article
- Variation in ultraviolet radiation and diabetes: evidence of an epigenetic effect that modulates diabetics' lifespan.Clinical epigenetics · 2013Article
- Twins for epigenetic studies of human aging and development.Ageing research reviews · 2013Review
- Cytomegalovirus seropositivity is associated with glucose regulation in the oldest old. Results from the Leiden 85-plus Study.Immunity & ageing : I & A · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Type 2 Diabetes Mellitus (T2DM) is a metabolic disorder influenced by interactions between genetic and environmental factors. Epigenetics conveys specific environmental influences into phenotypic traits through a variety of mechanisms that are often installed in early life, then persist in differentiated tissues with the power to modulate the expression of many genes, although undergoing time-dependent alterations. There is still no evidence that epigenetics contributes significantly to the causes or transmission of T2DM from one generation to another, thus, to the current environment-driven epidemics, but it has become so likely, as pointed out in this paper, that one can expect an efflorescence of epigenetic knowledge about T2DM in times to come.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.