ArticlePloS one2011
Impaired structural connectivity of socio-emotional circuits in autism spectrum disorders: a diffusion tensor imaging study.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 1 of them a synthesis that pooled it.
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Who cites it
56 citing papers in PubMed, 1 synthesis or guideline pooled it, 109 citations in OpenAlex.
- Atypical structural connectivity of language networks in autism spectrum disorder: A meta-analysis of diffusion tensor imaging studies.Autism research : official journal of the International Society for Autism Research · 2022Pooled it
- A two-step temporal data augmentation and supervised learning framework for predicting autism diagnosis at 36 months in patients with tuberous sclerosis complex.Computers in biology and medicine · 2026Article
- The Cortico-Cortical and Subcortical Circuits of the Human Brain Language Centers Including the Dual Limbic and Language Functioning Fiber Tracts.Brain sciences · 2026Review
- Combining functional, structural, and morphological networks for multimodal classification of developing autistic brains.Brain imaging and behavior · 2025Article
- Coactivation pattern analysis reveals altered whole-brain functional transient dynamics in autism spectrum disorder.European child & adolescent psychiatry · 2024Article
- Segregated Dynamical Networks for Biological Motion Perception in the Mu and Beta Range Underlie Social Deficits in Autism.Diagnostics (Basel, Switzerland) · 2024Article
- Altered structural connectome of children with auditory processing disorder: a diffusion MRI study.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Tract- and gray matter- based spatial statistics show white matter and gray matter microstructural differences in autistic males.Frontiers in neuroscience · 2023Article
- A narrative review of the anatomy and function of the white matter tracts in language production and comprehension.Frontiers in human neuroscience · 2023Review
- Connectivity in deep brain stimulation for self-injurious behavior: multiple targets for a common network?Frontiers in human neuroscience · 2022Article
- Developmental pattern of the cortical topology in high-functioning individuals with autism spectrum disorder.Human brain mapping · 2021Article
- Role of Oligodendrocytes and Myelin in the Pathophysiology of Autism Spectrum Disorder.Brain sciences · 2020Review
- Small Semantic Networks in Individuals with Autism Spectrum Disorder Without Intellectual Impairment: A Verbal Fluency Approach.Journal of autism and developmental disorders · 2020Article
- Age-related differences in white matter diffusion measures in autism spectrum condition.Molecular autism · 2020Article
- Diffusion Tensor Imaging Abnormalities in the Uncinate Fasciculus and Inferior Longitudinal Fasciculus in Phelan-McDermid Syndrome.Pediatric neurology · 2020Observational
- Fixel Based Analysis Reveals Atypical White Matter Micro- and Macrostructure in Adults With Autism Spectrum Disorder: An Investigation of the Role of Biological Sex.Frontiers in integrative neuroscience · 2020Article
- Anomalies in uncinate fasciculus development and social defects in preschoolers with autism spectrum disorder.BMC psychiatry · 2019Article
- White matter alterations in adult with autism spectrum disorder evaluated using diffusion kurtosis imaging.Neuroradiology · 2019Article
- Widespread Disrupted White Matter Microstructure in Autism Spectrum Disorders.Journal of autism and developmental disorders · 2019Article
- Cognitive impairment and autistic-like behaviour in SAPAP4-deficient mice.Translational psychiatry · 2019Article
Corrections and comments
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Authors and funding
9 authors at 6 institutions in 2 countries.
Funding
Abstract
backgroundAbnormal white matter development may disrupt integration within neural circuits, causing particular impairments in higher-order behaviours. In autism spectrum disorders (ASDs), white matter alterations may contribute to characteristic deficits in complex socio-emotional and communication domains. Here, we used diffusion tensor imaging (DTI) and tract based spatial statistics (TBSS) to evaluate white matter microstructure in ASD. METHODS/PRINCIPAL
findingsDTI scans were acquired for 19 children and adolescents with ASD (∼8-18 years; mean 12.4±3.1) and 16 age and IQ matched controls (∼8-18 years; mean 12.3±3.6) on a 3T MRI system. DTI values for fractional anisotropy, mean diffusivity, radial diffusivity and axial diffusivity, were measured. Age by group interactions for global and voxel-wise white matter indices were examined. Voxel-wise analyses comparing ASD with controls in: (i) the full cohort (ii), children only (≤12 yrs.), and (iii) adolescents only (>12 yrs.) were performed, followed by tract-specific comparisons. Significant age-by-group interactions on global DTI indices were found for all three diffusivity measures, but not for fractional anisotropy. Voxel-wise analyses revealed prominent diffusion measure differences in ASD children but not adolescents, when compared to healthy controls. Widespread increases in mean and radial diffusivity in ASD children were prominent in frontal white matter voxels. Follow-up tract-specific analyses highlighted disruption to pathways integrating frontal, temporal, and occipital structures involved in socio-emotional processing. CONCLUSIONS/SIGNIFICANCE: Our findings highlight disruption of neural circuitry in ASD, particularly in those white matter tracts that integrate the complex socio-emotional processing that is impaired in this disorder.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.