ArticlePloS one2011
Transcriptomic analyses during the transition from biomass production to lipid accumulation in the oleaginous yeast Yarrowia lipolytica.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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Who cites it
49 citing papers in PubMed.
- Lipid accumulation in nitrogen and phosphorus-limited yeast is caused by less growth-related dilution.Metabolic engineering · 2026Article
- Transcriptomic Analysis of Lipid Accumulation in Mucor circinelloides WJ11 Under Submerged and Solid-State Fermentation.Applied biochemistry and biotechnology · 2025Article
- High-throughput metabolic engineering ofProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Proteomic insights into the physiology and metabolism of oleaginous yeasts and filamentous fungi.Frontiers in microbiology · 2025Review
- Nitrogen starvation causes lipid remodeling in Rhodotorula toruloides.Microbial cell factories · 2024Article
- High-yield α-humulene production in Yarrowia lipolytica from waste cooking oil based on transcriptome analysis and metabolic engineering.Microbial cell factories · 2022Article
- Nitrogen Starvation Enhances the Production of Saturated and Unsaturated Fatty Acids inMarine drugs · 2022Article
- Altering the fatty acid profile of Yarrowia lipolytica to mimic cocoa butter by genetic engineering of desaturases.Microbial cell factories · 2022Article
- Increased Accumulation of Squalene in Engineered Yarrowia lipolytica through Deletion ofApplied and environmental microbiology · 2021Article
- Review
- Genome Sequence Analysis of the Oleaginous Yeast,Journal of fungi (Basel, Switzerland) · 2021Article
- Integrating Transcriptomics and Metabolomics to Characterize Metabolic Regulation to Elevated COMarine biotechnology (New York, N.Y.) · 2021Article
- Application of Random Mutagenesis and Synthetic FadR Promoter forFrontiers in bioengineering and biotechnology · 2021Article
- Nitrogen as the major factor influencing gene expression inBiotechnology reports (Amsterdam, Netherlands) · 2020Article
- Promoters for lipogenesis-specific downregulation in Yarrowia lipolytica.FEMS yeast research · 2020Article
- Negative Correlation between Lipid Content and Antibiotic Activity inAntibiotics (Basel, Switzerland) · 2020Article
- Expression of genes of the Pho regulon is altered in Streptomyces coelicolor.Scientific reports · 2020Article
- Application of Stable Isotope Tracing to Elucidate Metabolic Dynamics During Yarrowia lipolytica α-Ionone Fermentation.iScience · 2020Article
- Lipid and DHA-production in Aurantiochytrium sp. - Responses to nitrogen starvation and oxygen limitation revealed by analyses of production kinetics and global transcriptomes.Scientific reports · 2019Article
- Multi-Omics Analysis of Fatty Alcohol Production in Engineered YeastsFrontiers in genetics · 2019Article
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8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We previously developed a fermentation protocol for lipid accumulation in the oleaginous yeast Y. lipolytica. This process was used to perform transcriptomic time-course analyses to explore gene expression in Y. lipolytica during the transition from biomass production to lipid accumulation. In this experiment, a biomass concentration of 54.6 g(CDW)/l, with 0.18 g/g(CDW) lipid was obtained in ca. 32 h, with low citric acid production. A transcriptomic profiling was performed on 11 samples throughout the fermentation. Through statistical analyses, 569 genes were highlighted as differentially expressed at one point during the time course of the experiment. These genes were classified into 9 clusters, according to their expression profiles. The combination of macroscopic and transcriptomic profiles highlighted 4 major steps in the culture: (i) a growth phase, (ii) a transition phase, (iii) an early lipid accumulation phase, characterized by an increase in nitrogen metabolism, together with strong repression of protein production and activity; (iv) a late lipid accumulation phase, characterized by the rerouting of carbon fluxes within cells. This study explores the potential of Y. lipolytica as an alternative oil producer, by identifying, at the transcriptomic level, the genes potentially involved in the metabolism of oleaginous species.
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