ArticlePloS one2011
Long-term mortality in patients with tuberculous meningitis: a Danish nationwide cohort study.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Clinical Performance Measures for Neurocritical Care: A Statement for Healthcare Professionals from the Neurocritical Care Society.Neurocritical care · 2020Pooled it
- Factors influencing harmonized health data collection, sharing and linkage in Denmark and Switzerland: A systematic review.PloS one · 2019Pooled it
- Clinical Outcomes of Patients With Drug-Resistant Tuberculous Meningitis Treated With an Intensified Antituberculosis Regimen.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2017Trial
- Tuberculosis in Turkiye: Epidemiological insights and recommendations for progress.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2025Review
- Article
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- Hydrocephalus Caused by Tuberculous Meningitis in an Immunocompetent Young Adult: A Case Report.International medical case reports journal · 2023Article
- Influence of Strongyloides stercoralis Coinfection on the Presentation, Pathogenesis, and Outcome of Tuberculous Meningitis.The Journal of infectious diseases · 2022Article
- Cerebrospinal fluid concentrations of fluoroquinolones and carbapenems in tuberculosis meningitis.Frontiers in pharmacology · 2022Article
- Optic Nerve Sheath Ultrasound for the Detection and Monitoring of Raised Intracranial Pressure in Tuberculous Meningitis.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Article
- A statistical analysis plan for the Adjunctive Corticosteroids for Tuberculous meningitis in HIV-positive adults (ACT HIV) clinical trial.Wellcome open research · 2021Article
- Xpert MTB/RIF Ultra for the Diagnosis of Tuberculous Meningitis: A Small Step Forward.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020Article
- Characteristics and predictors for tuberculosis related mortality in Denmark from 2009 through 2014: A retrospective cohort study.PloS one · 2020Article
- Expression of autophagy-related genes in cerebrospinal fluid of patients with tuberculous meningitis.Experimental and therapeutic medicine · 2018Article
- Tuberculous meningitis in an immunocompetent male complicated by hydrocephalus.BMJ case reports · 2016Article
- Adjunctive role of MMP-9 inhibition along with conventional anti-tubercular drugs against experimental tuberculous meningitis.International journal of experimental pathology · 2016Article
- Hamsi scoring in the prediction of unfavorable outcomes from tuberculous meningitis: results of Haydarpasa-II study.Journal of neurology · 2015Article
- Major outcomes of patients with tuberculous meningitis on directly observed thrice a week regime.Annals of Indian Academy of Neurology · 2014Article
- Long-term mortality in patients with pulmonary and extrapulmonary tuberculosis: a Danish nationwide cohort study.Clinical epidemiology · 2014Article
- Presentation, Clinical Characteristics, and Treatment Outcomes among Tuberculous Meningitis Patients with and Without HIV Infection at Vajira Hospital, Thailand: A Retrospective Cohort Study.Journal of the International Association of Providers of AIDS CareArticle
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Authors and funding
6 authors.
Funding
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Abstract
backgroundWith high short-term mortality and substantial excess morbidity among survivors, tuberculous meningitis (TBM) is the most severe manifestation of extra-pulmonary tuberculosis (TB). The objective of this study was to assess the long-term mortality and causes of death in a TBM patient population compared to the background population.
methodsA nationwide cohort study was conducted enrolling patients notified with TBM in Denmark from 1972-2008 and alive one year after TBM diagnosis. Data was extracted from national registries. From the background population we identified a control cohort of individuals matched on gender and date of birth. Kaplan-Meier survival curves and Cox regression analysis were used to estimate mortality rate ratios (MRR) and analyse causes of death.
findingsA total of 55 TBM patients and 550 individuals from the background population were included in the study. Eighteen patients (32.7%) and 107 population controls (19.5%) died during the observation period. The overall MRR was 1.79 (95%CI: 1.09-2.95) for TBM patients compared to the population control cohort. TBM patients in the age group 31-60 years at time of diagnosis had the highest relative risk of death (MRR 2.68; 95%CI 1.34-5.34). The TBM patients had a higher risk of death due to infectious disease, but not from other causes of death.
conclusionAdult TBM patients have an almost two-fold increased long-term mortality and the excess mortality stems from infectious disease related causes of death.
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