ArticlePloS one2011
Vessel arterial-venous plasticity in adult neovascularization.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Isolated human adipose microvessels retain native microvessel structure and recapitulate sprouting angiogenesis.Angiogenesis · 2025Article
- Vascularized Tissue Organoids.Bioengineering (Basel, Switzerland) · 2023Review
- Isolation of ready-made rat microvessels and its applications in effective in vivo vascularization and in angiogenic studies in vitro.Nature protocols · 2022Review
- A Biofabrication Strategy for a Custom-Shaped, Non-Synthetic Bone Graft Precursor with a Prevascularized Tissue Shell.Frontiers in bioengineering and biotechnology · 2022Article
- Cellular Based Strategies for Microvascular Engineering.Stem cell reviews and reports · 2019Review
- Efficient differentiation of human embryonic stem cells to arterial and venous endothelial cells under feeder- and serum-free conditions.Stem cell research & therapy · 2015Article
- Large-scale time series microscopy of neovessel growth during angiogenesis.Angiogenesis · 2015Article
- Adipose-derived stromal vascular fraction cells isolated from old animals exhibit reduced capacity to support the formation of microvascular networks.Experimental gerontology · 2015Article
- Making microvascular networks work: angiogenesis, remodeling, and pruning.Physiology (Bethesda, Md.) · 2014Review
- Bioreactor for modulation of cardiac microtissue phenotype by combined static stretch and electrical stimulation.Biofabrication · 2014Article
- Encapsulation of adipose stromal vascular fraction cells in alginate hydrogel spheroids using a direct-write three-dimensional printing system.BioResearch open access · 2013Article
- Angiogenesis: an adaptive dynamic biological patterning problem.PLoS computational biology · 2013Article
- Manipulating the microvasculature and its microenvironment.Critical reviews in biomedical engineering · 2013Review
- Generation of a functional liver tissue mimic using adipose stromal vascular fraction cell-derived vasculatures.Scientific reports · 2013Article
- Microvascular repair: post-angiogenesis vascular dynamics.Microcirculation (New York, N.Y. : 1994) · 2012Review
- Role of the Pancreatic Islet Microvasculature in Health and Disease.The journal of histochemistry and cytochemistry : official journal of the Histochemistry SocietyReview
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
objectiveProper arterial and venous specification is a hallmark of functional vascular networks. While arterial-venous identity is genetically pre-determined during embryo development, it is unknown whether an analogous pre-specification occurs in adult neovascularization. Our goal is to determine whether vessel arterial-venous specification in adult neovascularization is pre-determined by the identity of the originating vessels. METHODS AND
resultsWe assessed identity specification during neovascularization by implanting isolated microvessels of arterial identity from both mice and rats and assessing the identity outcomes of the resulting, newly formed vasculature. These microvessels of arterial identity spontaneously formed a stereotypical, perfused microcirculation comprised of the full complement of microvessel types intrinsic to a mature microvasculature. Changes in microvessel identity occurred during sprouting angiogenesis, with neovessels displaying an ambiguous arterial-venous phenotype associated with reduced EphrinB2 phosphorylation.
conclusionsOur findings indicate that microvessel arterial-venous identity in adult neovascularization is not necessarily pre-determined and that adult microvessels display a considerable level of phenotypic plasticity during neovascularization. In addition, we show that vessels of arterial identity also hold the potential to undergo sprouting angiogenesis.
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