ArticlePloS one2011
Fate of transgenic DNA from orally administered Bt MON810 maize and effects on immune response and growth in pigs.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 82 citations in OpenAlex.
- Measuring the process and rate of exogenous DNA degradation during digestion in mice.Scientific reports · 2022Article
- Herbivorous Juvenile Grass Carp (Toxins · 2022Article
- Deficiencies in the Risk Assessment of Genetically Engineered Bt Cowpea Approved for Cultivation in Nigeria: A Critical Review.Plants (Basel, Switzerland) · 2022Review
- Horizontal gene transfer from genetically modified plants - Regulatory considerations.Frontiers in bioengineering and biotechnology · 2022Article
- Expression profiling of key pathways in rat liver after a one-year feeding trial with transgenic maize MON810.Scientific reports · 2019Article
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- Humoral and cellular immune response in Wistar Han RCC rats fed two genetically modified maize MON810 varieties for 90 days (EU 7th Framework Programme project GRACE).Archives of toxicology · 2018Article
- Transcriptomic Analysis of Intestinal Tissues from Two 90-Day Feeding Studies in Rats Using Genetically Modified MON810 Maize Varieties.Frontiers in genetics · 2017Article
- Possible health impacts of Bt toxins and residues from spraying with complementary herbicides in genetically engineered soybeans and risk assessment as performed by the European Food Safety Authority EFSA.Environmental sciences Europe · 2017Review
- Investigations of immunogenic, allergenic and adjuvant properties of Cry1Ab protein after intragastric exposure in a food allergy model in mice.BMC immunology · 2016Article
- Article
- Effect of dietary phytase transgenic corn on physiological characteristics and the fate of recombinant plant DNA in laying hens.Asian-Australasian journal of animal sciences · 2014Article
- Article
- Sequence-based analysis of the intestinal Microbiota of sows and their offspring fed genetically modified maize expressing a truncated form of Bacillus thuringiensis Cry1Ab protein (Bt Maize).Applied and environmental microbiology · 2013Article
- Article
- Article
- Cry1Ab treatment has no effects on viability of cultured porcine intestinal cells, but triggers Hsp70 expression.PloS one · 2013Article
- High-throughput sequence-based analysis of the intestinal microbiota of weanling pigs fed genetically modified MON810 maize expressing Bacillus thuringiensis Cry1Ab (Bt maize) for 31 days.Applied and environmental microbiology · 2012Article
- Effects of feeding Bt maize to sows during gestation and lactation on maternal and offspring immunity and fate of transgenic material.PloS one · 2012Article
- Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We assessed the effect of short-term feeding of genetically modified (GM: Bt MON810) maize on immune responses and growth in weanling pigs and determined the fate of the transgenic DNA and protein in-vivo. Pigs were fed a diet containing 38.9% GM or non-GM isogenic parent line maize for 31 days. We observed that IL-12 and IFNγ production from mitogenic stimulated peripheral blood mononuclear cells decreased (P<0.10) following 31 days of GM maize exposure. While Cry1Ab-specific IgG and IgA were not detected in the plasma of GM maize-fed pigs, the detection of the cry1Ab gene and protein was limited to the gastrointestinal digesta and was not found in the kidneys, liver, spleen, muscle, heart or blood. Feeding GM maize to weanling pigs had no effect on growth performance or body weight. IL-6 and IL-4 production from isolated splenocytes were increased (P<0.05) in response to feeding GM maize while the proportion of CD4(+) T cells in the spleen decreased. In the ileum, the proportion of B cells and macrophages decreased while the proportion of CD4(+) T cells increased in GM maize-fed pigs. IL-8 and IL-4 production from isolated intraepithelial and lamina propria lymphocytes were also increased (P<0.05) in response to feeding GM maize. In conclusion, there was no evidence of cry1Ab gene or protein translocation to the organs and blood of weaning pigs. The growth of pigs was not affected by feeding GM maize. Alterations in immune responses were detected; however, their biologic relevance is questionable.
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