ArticleFrontiers in psychiatry2011
Adults with attention-deficit/hyperactivity disorder - a brain magnetic resonance spectroscopy study.
Article in Frontiers in psychiatry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Emerging findings of glutamate-glutamine imbalance in the medial prefrontal cortex in attention deficit/hyperactivity disorder: systematic review and meta-analysis of spectroscopy studies.European archives of psychiatry and clinical neuroscience · 2022Pooled it
- Glutamate imbalance in key structure of the default mode network in adults with attention-deficit/hyperactivity disorder.European archives of psychiatry and clinical neuroscience · 2025Article
- Aberrant glutamatergic systems underlying impulsive behaviors: Insights from clinical and preclinical research.Progress in neuro-psychopharmacology & biological psychiatry · 2024Review
- Glutamate receptor genetic variants affected peripheral glutamatergic transmission and treatment induced improvement of Indian ADHD probands.Scientific reports · 2023Article
- Cross-attractor modeling of resting-state functional connectivity in psychiatric disorders.NeuroImage · 2023Article
- The electroretinogram b-wave amplitude: a differential physiological measure for Attention Deficit Hyperactivity Disorder and Autism Spectrum Disorder.Journal of neurodevelopmental disorders · 2022Article
- Reduced Glx and GABA Inductions in the Anterior Cingulate Cortex and Caudate Nucleus Are Related to Impaired Control of Attention in Attention-Deficit/Hyperactivity Disorder.International journal of molecular sciences · 2022Article
- Precision Medicine Care in ADHD: The Case for Neural Excitation and Inhibition.Brain sciences · 2021Article
- Altered brain metabolism contributes to executive function deficits in school-aged children born very preterm.Pediatric research · 2020Article
- Neuroinflammation as a risk factor for attention deficit hyperactivity disorder.Pharmacology, biochemistry, and behavior · 2019Review
- The pharmacology of amphetamine and methylphenidate: Relevance to the neurobiology of attention-deficit/hyperactivity disorder and other psychiatric comorbidities.Neuroscience and biobehavioral reviews · 2018Review
- Event-Related-Potential (ERP) Correlates of Performance Monitoring in Adults With Attention-Deficit Hyperactivity Disorder (ADHD).Frontiers in psychology · 2018Article
- Changes in serum levels of kynurenine metabolites in paediatric patients affected by ADHD.European child & adolescent psychiatry · 2017Article
- Fronto-striatal glutamate in children with Tourette's disorder and attention-deficit/hyperactivity disorder.NeuroImage. Clinical · 2017Article
- Impulsivity and Aggression in Female BPD and ADHD Patients: Association with ACC Glutamate and GABA Concentrations.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Article
- Developmental changes in gamma-aminobutyric acid levels in attention-deficit/hyperactivity disorder.Translational psychiatry · 2015Article
- Normal Neurochemistry in the Prefrontal and Cerebellar Brain of Adults with Attention-Deficit Hyperactivity Disorder.Frontiers in behavioral neuroscience · 2015Article
- Aberrant glutamate signaling in the prefrontal cortex and striatum of the spontaneously hypertensive rat model of attention-deficit/hyperactivity disorder.Psychopharmacology · 2014Article
- Glutamate/glutamine and neuronal integrity in adults with ADHD: a proton MRS study.Translational psychiatry · 2014Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundImpaired cognitive control in individuals with attention-deficit/hyperactivity disorder (ADHD) may be related to a prefrontal cortical glutamatergic deficit. We assessed the glutamate level in the left and the right midfrontal region including the anterior cingulate cortex in adults with ADHD and healthy controls.
methodsTwenty-nine adults with ADHD and 38 healthy controls were included. We used Proton Magnetic Resonance Imaging with single voxel point-resolved spectroscopy to measure the ratio of glutamate to creatine (Glu/Cre) in the left and the right midfrontal region in the two groups.
resultsThe ADHD group showed a significant reduction of Glu/Cre in the left midfrontal region compared to the controls.
conclusionThe reduction of Glu/Cre in the left midfrontal region in the ADHD group may reflect a glutamatergic deficit in prefrontal neuronal circuitry in adults with ADHD, resulting in problems with cognitive control.
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