Trial reportSleep2011
MSLT in primary insomnia: stability and relation to nocturnal sleep.
Trial report in Sleep, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 79 citations in OpenAlex.
- Insomnia nosology: a systematic review and critical appraisal of historical diagnostic categories and current phenotypes.Journal of sleep research · 2023Pooled it
- A Mechanistic study assessing difficulty discontinuing chronic hypnotic use.Psychopharmacology · 2025Trial
- Sleep and pain in humans with fibromyalgia and comorbid insomnia: double-blind, crossover study of suvorexant 20 mg versus placebo.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2020Trial
- Hyperarousal in insomnia: pre-sleep and diurnal cortisol levels in response to chronic zolpidem treatment.Sleep medicine · 2019Trial
- Hyperarousal in insomnia and hypnotic dose escalation.Sleep medicine · 2016Trial
- Excessive Daytime Sleepiness Should Be Systematically Assessed in Individuals With Insomnia: A Population-Based Study Employing a Virtual Agent-Based Digital Tool.Journal of sleep research · 2026Article
- Insomnia Symptoms Are Associated with Measures of Functional Deterioration and Dementia Status in Adults with Down Syndrome at High Risk for Alzheimer's Disease.Journal of Alzheimer's disease : JAD · 2024Article
- Insomnia with physiological hyperarousal is associated with lower weight: a novel finding and its clinical implications.Translational psychiatry · 2021Article
- The Different Faces of Insomnia.Frontiers in psychiatry · 2021Article
- Enhanced Vigilance Stability during Daytime in Insomnia Disorder.Brain sciences · 2020Article
- Nocturnal cognitive arousal is associated with objective sleep disturbance and indicators of physiologic hyperarousal in good sleepers and individuals with insomnia disorder.Sleep medicine · 2020Article
- Acute and Chronic Insomnia: What Has Time and/or Hyperarousal Got to Do with It?Brain sciences · 2020Article
- Article
- Ultrasound guided injections of botulinum toxin type A into stellate ganglion to treat insomnia.Experimental and therapeutic medicine · 2017Article
- Objective short sleep duration modifies the relationship between hypertension and all-cause mortality.Journal of hypertension · 2017Article
- Article
- Towards quantitative cutoffs for insomnia: how current diagnostic criteria mischaracterize remission.Sleep medicine · 2016Article
- Article
- Differential sleep, sleepiness, and neurophysiology in the insomnia phenotypes of shift work disorder.Sleep · 2015Observational
- The nature of stable insomnia phenotypes.Sleep · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
STUDY
objectivesTo assess the stability of the multiple sleep latency test (MSLT) in primary insomnia and its relation to total sleep time.
designRandomized, double-blind, placebo controlled, clinical trial.
settingOutpatient with sleep laboratory assessments in months 1 and 8 of treatment.
participantsNinety-five primary insomniacs, 32-64 years old and 55 age- and sex-matched general population-based, representative controls.
interventionsAfter a screening nocturnal polysomnograms (NPSG) and MSLT the following day, participants with primary insomnia were randomized to take zolpidem 10 mg (n = 50) or placebo (n = 45) nightly for 12 months. During months 1 and 8, while taking their prescribed treatments, NPSGs and MSLTs the following day were conducted. A population-based sample served as controls and received a single NPSG followed by MSLT.
resultsMean daily sleep latency on the screening MSLT of insomniacs was normally distributed across the full range of MSLT scores and significantly higher than those of a population-based representative control sample (P < 0.006). The insomniacs with the highest screening MSLTs had the shortest screening total sleep times (P < 0.05). The MSLTs of insomniacs during treatment in study month 1 were correlated (r = 0.44, P < 0.001) with their month 8 MSLT. The mean MSLT score of the zolpidem group did not differ from that of the placebo group, and the stability within treatment groups also did not differ.
conclusionsThese data support the hypothesis that some insomniacs show a reliable disorder of hyperarousal with increased wake drive both at night and during the day.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.