Evidence map›Paper›PMID 22131599›Full record

Trial reportSleep2011

The effect of exercise training on obstructive sleep apnea and sleep quality: a randomized controlled trial.

Christopher E Kline, E Patrick Crowley, Gary B Ewing, James B Burch, Steven N Blair, J Larry Durstine, J Mark Davis, Shawn D Youngstedt

5 registry-linked trialsOpen access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Sleep, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 5 registered trials, which are not on this map. Cited by 158 papers, 17 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
158citing papers in PubMed, 17 pooled it
11.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00956423 phase1 / phase2completednot on this map

Exercise: A Novel Treatment for Obstructive Sleep Apnea

TypeinterventionalSponsorUniversity of South CarolinaRan2009 to 2011Enrolled43ConditionsObstructive Sleep ApneaArmsmoderate-intensity aerobic and resistance training, low-intensity stretching
NCT02559427 nawithdrawnnot on this mapstarted 2016, after this paper: background citation

Impact of 3-week SPA Therapy on Sleep Apnea in Patients With Obstructive Sleep Apnea Syndrome and Chronic Venous Insufficiency: A Randomized, Controlled Study

TypeinterventionalSponsorAssociation Francaise pour la Recherche ThermaleRan2016 to 2019Enrolled0ConditionsObstructive Sleep Apnea Syndrome, Chronic Venous InsufficiencyArms3-week immediate SPA treatment, 3-week late SPA treatment
NCT02963844 nacompletednot on this mapstarted 2016, after this paper: background citation

The Inspiratory Muscle Training Improves the Severity of Obstructive Sleep Apnea and Sleep Quality?

TypeinterventionalSponsorUniversidade Federal de PernambucoRan2016 to 2020Enrolled16ConditionsSleep Apnea, ObstructiveArmsInspiratory Muscle Training, Inspiratory Muscle Training Sham
NCT04120428 naunknown statusnot on this mapstarted 2020, after this paper: background citation

Effects of a 24-week Aquatic Exercise Training Program on Obstructive Sleep Apnea Severity in Elderly Women

TypeinterventionalSponsorFederal University of ParaíbaRan2020 to 2020Enrolled32ConditionsObstructive Sleep Apnea, Sleep-disordered Breathing, Sleep Disorder, Breathing-RelatedArmsAquatic exercise training program
NCT06087900 nacompletednot on this mapstarted 2022, after this paper: background citation

Effects of Different Exercise Modalities on Apnea-Hypopnea Index and Oxidative Stress in Patients With Obstructive Sleep Apnea.

TypeinterventionalSponsorChulalongkorn UniversityRan2022 to 2023Enrolled40ConditionsObstructive Sleep ApneaArmsModerate continuous training (MICT), High intensity interval training (HIIT), Inspiratory muscle training (IMT), Control
3 · Its place in the literature

Who cites it

158 citing papers in PubMed, 17 syntheses or guidelines pooled it, 345 citations in OpenAlex.

  1. Effectiveness of aerobic exercise training in patients with obstructive sleep apnea: a systematic review and meta-analysis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
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  8. Effects of aerobic exercise and resistance training on obstructive sleep apnea: a systematic review and meta-analysis.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2024
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  9. Effects of different types of exercise on sleep quality based on Pittsburgh Sleep Quality Index in middle-aged and older adults: a network meta-analysis.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2024
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  12. Effects of Exercise on Patients with Obstructive Sleep Apnea: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2022
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98 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Christopher E KlineDepartment of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA. klinec@upmc.edu
E Patrick Crowley
Gary B Ewing
James B Burch
Steven N Blair
J Larry Durstine
J Mark Davis
Shawn D Youngstedt
University of South Carolina · USWm. Jennings Bryan Dorn VA Medical Center · USUniversity of Pittsburgh Medical Center · US

Funding

Translational Research Training in Sleep MedicineT32HL082610 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Daniel J. Buysse, PETER L FRANZEN · 2007 to 2026
$5.8M
Exercise: A Novel Treatment for Obstructive Sleep ApneaR36CD000695 · CD · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI KLINE, CHRISTOPHER EDWARD · 2008 to 2008
$38k
NHLBI NIH HHS T32 HL082610NHLBI NIH HHS T32 HL082610-04ODCDC CDC HHS 1R36CD000695-1ODCDC CDC HHS R36 CD000695
6 · The paper itself

Abstract

STUDY

objectivesTo evaluate the efficacy of a 12-week exercise training program for reducing obstructive sleep apnea (OSA) severity and improving sleep quality, and to explore possible mechanisms by which exercise may reduce OSA severity.

designRandomized controlled trial.

settingClinical exercise physiology center, sleep laboratory.

participantsForty-three sedentary and overweight/obese adults aged 18-55 years with at least moderate-severity untreated OSA (screening apnea-hypopnea index [AHI] ≥ 15).

interventionsParticipants randomized to exercise training (n = 27) met 4 times/week for 12 weeks and performed 150 min/week of moderate-intensity aerobic activity, followed by resistance training twice/week. Participants randomized to a stretching control (n = 16) met twice weekly for 12 weeks to perform low-intensity exercises designed to increase whole-body flexibility. MEASUREMENTS AND

resultsOSA severity was assessed with one night of laboratory polysomnography (PSG) before and following the 12-week intervention. Measures of sleep quality included PSG, actigraphy (7-10 days), and the Pittsburgh Sleep Quality Index. Compared with stretching, exercise resulted in a significant AHI reduction (exercise: 32.2 ± 5.6 to 24.6 ± 4.4, stretching: 24.4 ± 5.6 to 28.9 ± 6.4; P < 0.01) as well as significant changes in oxygen desaturation index (ODI; P = 0.03) and stage N3 sleep (P = 0.03). Reductions in AHI and ODI were achieved without a significant decrease in body weight. Improvements in actigraphic sleep and subjective sleep quality were also noted following exercise compared with stretching.

conclusionsExercise training had moderate treatment efficacy for the reduction of AHI in sedentary overweight/obese adults, which suggests that exercise may be beneficial for the management of OSA beyond simply facilitating weight loss.

trial registrationClinicaltrials.gov identification number NCT00956423.

Indexed as

Exercise TherapySleepAdolescentAdultFeeding BehaviorFemaleHumansLife StyleMaleMiddle AgedObesityPatient CompliancePolysomnographySeverity of Illness IndexSleep Apnea, ObstructiveYoung AdultActigraphyexercise trainingobstructive sleep apneapolysomnographyrandomized controlled trialsleep quality

Identifiers

PMID22131599
PMCPMC3208839
OpenAlexW1974402435

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.