ArticleThe journal of histochemistry and cytochemistry : official journal of the Histochemistry Society2012
The human submandibular gland: immunohistochemical analysis of SNAREs and cytoskeletal proteins.
Article in The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 22 citations in OpenAlex.
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- Morphological and histochemical characterization of the secretory epithelium in the canine lacrimal gland.European journal of histochemistry : EJH · 2021Article
- A comprehensive review of the influence of Epigallocatechin gallate on Sjögren's syndrome associated molecular regulators of exocytosis (Review).Biomedical reports · 2021Review
- Neurofibromin expression by normal salivary glands.Head & face medicine · 2021Article
- VIP and muscarinic synergistic mucin secretion by salivary mucous cells is mediated by enhanced PKC activity via VIP-induced release of an intracellular CaPflugers Archiv : European journal of physiology · 2020Article
- Saliva and Blood Asprosin Hormone Concentration Associated with Obesity.International journal of endocrinology · 2019Article
- Molecular Regulatory Mechanism of Exocytosis in the Salivary Glands.International journal of molecular sciences · 2018Review
- β-adrenoceptor activation increased VAMP-2 and syntaxin-4 in secretory granules are involved in protein secretion of submandibular gland through the PKA/F-actin pathway.Bioscience reports · 2018Article
- Canine Salivary Glands: Analysis of Rab and SNARE Protein Expression and SNARE Complex Formation With Diverse Tissue Properties.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2017Article
- Ultrastructure and immunohistochemical characterization of proteins concerned with the secretory machinery in goat ceruminous glands.European journal of histochemistry : EJH · 2017Article
- Alteration of microRNA expressions in the pons and medulla in rats after 3,3'-iminodipropionitrile administration.Journal of toxicologic pathology · 2016Article
- Labial Salivary Glands in Infants: Histochemical Analysis of Cytoskeletal and Antimicrobial Proteins.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2016Article
- Histatin-1 Expression in Human Lacrimal Epithelium.PloS one · 2016Article
- Actin depolymerisation and crosslinking join forces with myosin II to contract actin coats on fused secretory vesicles.Journal of cell science · 2015Article
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Submandibular acinar glands secrete numerous proteins such as digestive enzymes and defense proteins on the basis of the exocrine secretion mode. Exocytosis is a complex process, including a soluble NSF attachment protein receptor (SNARE)-mediated membrane fusion of vesicles and target membrane and the additional activation of cytoskeletal proteins. Relevant data are available predominantly for animal salivary glands, especially of the rat parotid acinar cells. The authors investigated the secretory molecular machinery of acinar (serous) cells in the human submandibular gland by immunohistochemistry and immunofluorescence and found diverse proteins associated with exocytosis for the first time. SNAP-23, syntaxin-2, syntaxin-4, and VAMP-2 were localized at the luminal plasma membrane; syntaxin-2 and septin-2 were expressed in vesicles in the cytoplasm. Double staining of syntaxin-2 and septin-2 revealed a colocalization on the same vesicles. Lactoferrin and α-amylase served as a marker for secretory vesicles and were labeled positively together with syntaxin-2 and septin-2 in double-staining procedures. Cytoskeletal components such as actin, myosin II, cofilin, and profilin are concentrated at the apical plasma membrane of acinar submandibular glands. These observations complement the understanding of the complex exocytosis mechanisms.
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