Trial reportThorax2012
Nocturnal temperature controlled laminar airflow for treating atopic asthma: a randomised controlled trial.
Trial report in Thorax, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 31 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Airsonett Airshower in Allergic Asthma a Double-blind Randomized Multi-centre Trial
A Prospective, Single Arm, Cohort Study of Nocturnal Temperature-controlled Laminar Airflow (TLA) Treatment (Airsonett®) in Patients With Allergic Asthma to Determine the Effect of Long-term Treatment on Exacerbation Frequency.
Temperature Controlled Laminar Airflow (TLA) Treatment of Moderate to Severe Atopic Eczema in Children and Adolescents - a Randomized Placebo Controlled Phase 2 Study
Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 70 citations in OpenAlex.
- Effectiveness of the Air Purification Strategies for the Treatment of Allergic Asthma: A Meta-Analysis.International archives of allergy and immunology · 2020Pooled it
- Analysis of sources and sinks of indoor particulate matter reveals insights into the real-world efficacy of portable air cleaners in a randomized intervention trial.The Science of the total environment · 2025Trial
- Temperature-controlled Laminar Airflow (TLA) in symptomatic severe asthma - a post hoc analysis of severe exacerbations, quality of life and health economics.BMC pulmonary medicine · 2022Trial
- Efficacy of indoor air purification in the treatment of Artemisia pollen-allergic rhinitis: A randomised, double-blind, clinical controlled trial.Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery · 2020Trial
- Trial
- House dust mite allergen avoidance strategies for the treatment of allergic asthma: A hypothesis-generating meta-analysis.The World Allergy Organization journal · 2024Review
- Uncontrolled asthma in school-aged children-a nationwide specialist care study.The journal of allergy and clinical immunology. Global · 2024Article
- Recent Advances in Long-Term Management of Asthma.Indian journal of pediatrics · 2022Review
- The nanotopography of SiONanoscale · 2021Article
- Temperature-controlled laminar airflow in adult atopic dermatitis patients - an observational study.Journal of the European Academy of Dermatology and Venereology : JEADV · 2021Observational
- The Efficacy of the Dyson Air Purifier in Improving Asthma Control: Protocol for a Single-Center, Investigator-Led, Randomized, Double-Blind, Placebo-Controlled Trial.JMIR research protocols · 2021Article
- Experimental and simulated evaluations of airborne contaminant exposure in a room with a modified localized laminar airflow system.Environmental science and pollution research international · 2021Article
- Effect of nocturnal Temperature-controlled Laminar Airflow on the reduction of severe exacerbations in patients with severe allergic asthma: a meta-analysis.European clinical respiratory journal · 2021Article
- Bringing asthma care into the twenty-first century.NPJ primary care respiratory medicine · 2020Review
- Association Between Bedroom Particulate Matter Filtration and Changes in Airway Pathophysiology in Children With Asthma.JAMA pediatrics · 2020Observational
- Asthma/Rhinitis (The United Airway) and Allergy: Chicken or Egg; Which Comes First?Journal of clinical medicine · 2020Review
- Modern Innovative Solutions to Improve Outcomes in Asthma, Breathlessness, and Chronic Obstructive Pulmonary Disease (MISSION ABC): Protocol for a Mixed-Methods Study.JMIR research protocols · 2019Article
- What is New in the Management of Childhood Asthma?Indian journal of pediatrics · 2018Review
- Diagnosis and treatment of severe asthma: a phenotype-based approach.Clinical medicine (London, England) · 2018Review
- Nordic consensus statement on the systematic assessment and management of possible severe asthma in adults.European clinical respiratory journal · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 7 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo determine whether environmental control using nocturnal temperature controlled laminar airflow (TLA) treatment could improve the quality of life of patients with persistent atopic asthma.
designRandomised, double-blind, placebo-controlled, parallel-group trial. Setting Nineteen European asthma clinics.
participants312 patients aged 7-70 with inadequately controlled persistent atopic asthma.
main outcome measureProportion of patients with an increase of ≥0.5 points in asthma quality of life score after 1 year of treatment.
resultsTLA devices were successfully installed in the bedrooms of 282 (90%) patients included in the primary efficacy analysis. There was a difference in treatment response rate between active (143 of 189, 76%) and placebo (56 of 92, 61%) groups, difference 14.8% (95% CI 3.1 to 26.5, p=0.02).3 In patients aged ≥12, on whom the study was powered, the difference in response rate was similar-active 106 of 143 (74%), placebo 42 of 70 (60%), difference 14.1% (0.6 to 27.7, p=0.059). There was a difference between groups in fractional exhaled nitric oxide change of -7.1 ppb (-13.6 to -0.7, p=0.03). Active treatment was associated with less increase in cat-specific IgE than placebo. There was no difference in adverse event rates between treatment groups.
conclusionInhalant exposure reduction with TLA improves quality of life, airway inflammation and systemic allergy in patients with persistent atopic asthma. TLA may be a treatment option for patients with inadequately controlled persistent atopic asthma. Trial registration number Clinical Trials NCT00986323.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.