ReviewSeminars in immunopathology2012
Exploring Staphylococcus aureus pathways to disease for vaccine development.
Review in Seminars in immunopathology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 36 citations in OpenAlex.
- Antibiotic Resistance ofPharmaceuticals (Basel, Switzerland) · 2025Review
- Select Whole-Cell Biofilm-Based Immunogens Protect against a Virulent Staphylococcus Isolate in a Stringent Implant Model of Infection.Vaccines · 2022Article
- Analysis of Antioxidant Capacity and Antimicrobial Properties of Selected Polish Grape Vinegars Obtained by Spontaneous Fermentation.Molecules (Basel, Switzerland) · 2021Article
- The Role of Macrophages inFrontiers in immunology · 2020Review
- PPE37 Is Essential forInfection and immunity · 2019Article
- Essential Domain-Dependent Roles Within Soluble IgG forFrontiers in immunology · 2018Article
- Attenuation of Staphylococcus aureus-Induced Bacteremia by Human Mini-Antibodies Targeting the Complement Inhibitory Protein Efb.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Vaccine protection of leukopenic mice against Staphylococcus aureus bloodstream infection.Infection and immunity · 2014Article
- Mouse models for infectious diseases caused by Staphylococcus aureus.Journal of immunological methods · 2014Review
- Models matter: the search for an effective Staphylococcus aureus vaccine.Nature reviews. Microbiology · 2014Review
- Where does a Staphylococcus aureus vaccine stand?Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2014Review
- Phagocytosis escape by a Staphylococcus aureus protein that connects complement and coagulation proteins at the bacterial surface.PLoS pathogens · 2013Article
- Evaluation of the protective immunity of a novel subunit fusion vaccine in a murine model of systemic MRSA infection.PloS one · 2013Article
- Vaccination with a UV-irradiated genetically attenuated mutant of Staphylococcus aureus provides protection against subsequent systemic infection.The Journal of infectious diseases · 2012Article
- Abscess formation and alpha-hemolysin induced toxicity in a mouse model of Staphylococcus aureus peritoneal infection.Infection and immunity · 2012Article
- Protein A-specific monoclonal antibodies and prevention of Staphylococcus aureus disease in mice.Infection and immunity · 2012Article
- Coagulases as determinants of protective immune responses against Staphylococcus aureus.Infection and immunity · 2012Article
- The potential use of toxin antibodies as a strategy for controlling acute Staphylococcus aureus infections.Expert opinion on therapeutic targets · 2012Review
- The iron-regulated staphylococcal lipoproteins.Frontiers in cellular and infection microbiology · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Staphylococcus aureus is a commensal of the human skin or nares and a pathogen that frequently causes skin and soft tissue infections as well as bacteremia and sepsis. Recent efforts in understanding the molecular mechanisms of pathogenesis revealed key virulence strategies of S. aureus in host tissues: bacterial scavenging of iron, induction of coagulation pathways to promote staphylococcal agglutination in the vasculature, and suppression of innate and adaptive immune responses. Advances in all three areas have been explored for opportunities in vaccine design in an effort to identify the critical protective antigens of S. aureus. Human clinical trials with specific subunit vaccines have failed, yet provide important insights for the design of future trials that must address the current epidemic of S. aureus infections with drug-resistant isolates (MRSA, methicillin-resistant S. aureus).
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.