ArticleJournal of virology2012
Multiple defects, including premature apoptosis, prevent Kaposi's sarcoma-associated herpesvirus replication in murine cells.
Article in Journal of virology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Immunologic Crosstalk of Endoplasmic Reticulum Stress Signaling in Bladder Cancer.Current cancer drug targets · 2024Review
- A Kaposi's sarcoma-associated herpes virus-encoded microRNA contributes to dilated cardiomyopathy.Signal transduction and targeted therapy · 2023Article
- Age-dependent regulation of SARS-CoV-2 cell entry genes and cell death programs correlates with COVID-19 severity.Science advances · 2021Article
- Bone Marrow-Derived SH-SY5Y Neuroblastoma Cells Infected with Kaposi's Sarcoma-Associated Herpesvirus Display Unique Infection Phenotypes and Growth Properties.Journal of virology · 2021Article
- Age-dependent regulation of SARS-CoV-2 cell entry genes and cell death programs correlates with COVID-19 disease severity.bioRxiv : the preprint server for biology · 2020Article
- Article
- PDGFRA defines the mesenchymal stem cell Kaposi's sarcoma progenitors by enabling KSHV oncogenesis in an angiogenic environment.PLoS pathogens · 2019Article
- Inhibition of Tip60 Reduces Lytic and Latent Gene Expression of Kaposi's Sarcoma-Associated Herpes Virus (KSHV) and Proliferation of KSHV-Infected Tumor Cells.Frontiers in microbiology · 2018Article
- Recombinant Murine Gamma Herpesvirus 68 Carrying KSHV G Protein-Coupled Receptor Induces Angiogenic Lesions in Mice.PLoS pathogens · 2015Article
- Structural proteins of Kaposi's sarcoma-associated herpesvirus antagonize p53-mediated apoptosis.Oncogene · 2015Article
- The role of endoplasmic reticulum stress in human pathology.Annual review of pathology · 2015Review
- Humanized-BLT mouse model of Kaposi's sarcoma-associated herpesvirus infection.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Article
- The viral KSHV chemokine vMIP-II inhibits the migration of Naive and activated human NK cells by antagonizing two distinct chemokine receptors.PLoS pathogens · 2013Article
- A unique herpesviral transcriptional program in KSHV-infected lymphatic endothelial cells leads to mTORC1 activation and rapamycin sensitivity.Cell host & microbe · 2013Article
- Abortive lytic reactivation of KSHV in CBF1/CSL deficient human B cell lines.PLoS pathogens · 2013Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The development of a mouse model for Kaposi's sarcoma-associated herpesvirus (KSHV) infection has been impeded by the limited host range of the virus. Here, we have examined the molecular basis of this host range restriction. KSHV efficiently enters murine cells and establishes latency. However, ectopic expression of the lytic switch protein RTA (replication and transcription activator) in these cells induces little viral gene expression and no virus production. Upon treatment with histone deacetylase inhibitors, KSHV-infected murine cells display more extensive but aberrant viral transcription and do not support either viral DNA synthesis or the production of infectious virions. These aberrantly infected cells also display markedly enhanced apoptosis. Genetic ablation of the mitochondrial apoptotic pathway in these cells prolongs their survival and permits viral DNA replication but does not rescue the generation of virions. We conclude that multiple defects, both prior to and following DNA synthesis, restrict lytic KSHV infection in murine cells.
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