ReviewActa biochimica et biophysica Sinica2012
Janus kinase 3: the controller and the controlled.
Review in Acta biochimica et biophysica Sinica, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 23 citations in OpenAlex.
- Identification of novelFrontiers in genetics · 2026Article
- Apoptosis and eryptosis: similarities and differences.Apoptosis : an international journal on programmed cell death · 2024Review
- Janus Kinase 3 Deficiency Promotes Vascular Reendothelialization-Brief Report.Arteriosclerosis, thrombosis, and vascular biology · 2021Article
- The Effects of Tofacitinib-Mediated Janus Kinase/Signal Transducers and Activators of the Transcription Signal Pathway Inhibition on Collagen Biosynthesis in Hepatic and Skin Fibroblast Cell Culture.Archives of rheumatology · 2020Article
- Understanding the structural features of JAK2 inhibitors: a combined 3D-QSAR, DFT and molecular dynamics study.Molecular diversity · 2019Article
- JAK3 mutations in Italian patients affected by SCID: New molecular aspects of a long-known gene.Molecular genetics & genomic medicine · 2018Article
- Tumor-specific delivery of therapeutic siRNAs by anti-EGFR immunonanoparticles.International journal of nanomedicine · 2018Article
- Janus Kinase 3, a Novel Regulator for Smooth Muscle Proliferation and Vascular Remodeling.Arteriosclerosis, thrombosis, and vascular biology · 2017Article
- The brain parenchyma has a type I interferon response that can limit virus spread.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Phosphatidic Acid Increases Epidermal Growth Factor Receptor Expression by Stabilizing mRNA Decay and by Inhibiting Lysosomal and Proteasomal Degradation of the Internalized Receptor.Molecular and cellular biology · 2015Article
- Lack of association between JAK3 gene polymorphisms and cardiovascular disease in Spanish patients with rheumatoid arthritis.BioMed research international · 2015Article
- WHI-P154 enhances the chemotherapeutic effect of anticancer agents in ABCG2-overexpressing cells.Cancer science · 2014Article
- Inflammatory pathways of importance for management of inflammatory bowel disease.World journal of gastroenterology · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Janus kinase (JAK)-signal transducer and activators of transcription (STAT) signaling pathways play crucial roles in lymphopoiesis. In particular, JAK3 has unique functions in the lymphoid system such that JAK3 ablation results in phenotypes resembling severe combined immunodeficiency syndrome. This review focuses on the biochemistry, immunological functions, and clinical significance of JAK3. Compared with other members of the JAK family, the biochemical properties of JAK3 are relatively less well characterized and thus largely inferred from studies of JAK2. Furthermore, new findings concerning the cross-talks between Notch and JAK signaling pathways through ubiquitin-mediated protein degradation are discussed in more detail.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.