ArticleSeizure2012
Co-morbidity of epilepsy in Tanzanian children: a community-based case-control study.
Article in Seizure, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 2 syntheses or guidelines pooled it, 27 citations in OpenAlex.
- Comorbidities of epilepsy in low and middle-income countries: systematic review and meta-analysis.Scientific reports · 2020Pooled it
- Oxcarbazepine add-on for drug-resistant focal epilepsy.The Cochrane database of systematic reviews · 2020Pooled it
- Growth parameters and childhood epilepsy in Hai District, Tanzania: a community-based study.Epilepsy research · 2014Trial
- Depression and associated factors among people with epilepsy at Wolaita Sodo University Hospital, South Ethiopia.Discover mental health · 2025Article
- Neuropsychology and Electroencephalography in Rural Children at Neurodevelopmental Risk: A Scoping Review.Pediatric reports · 2023Article
- Teachers and Epilepsy in Saudi Arabia: Gaps in Knowledge and Potential Roles.International journal of general medicine · 2022Review
- Clinical characteristics of epilepsy in resource-limited communities in Punjab, Northwest India.Epilepsia open · 2020Article
- Cognition and behavior in a prevalent cohort of children with epilepsy in rural northern Tanzania: A three-year follow-up study.Epilepsy & behavior : E&B · 2015Article
- Epidemiology, causes, and treatment of epilepsy in sub-Saharan Africa.The Lancet. Neurology · 2014Review
Corrections and comments
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Authors and funding
10 authors at 7 institutions in 2 countries.
Funding
Abstract
purposeTo define the prevalence and associations of co-morbidity and school attendance in older children with epilepsy (CWE) from a rural district of Tanzania by conducting a community-based case-control study.
methodsChildren aged 6-14 years old with active epilepsy (at least two unprovoked seizures in the last five years) were identified in a cross-sectional survey in Tanzania. Co-morbidities were assessed and cases were compared with age-matched controls.
resultsCo-morbidity was very common amongst cases (95/112, 85%), with 62/112 (55%) having multiple co-morbidities. Co-morbidities consisted of cognitive impairment (72/112, 64%), behaviour disorder 68/112 (61%), motor difficulties 29/112 (26%), burns and other previous injuries (29/112, 26%). These complications were significantly more common in cases than in controls (odds ratio 14.8, 95%CI 7.6-28.6, p<0.001). Co-morbidity in CWE was associated with structural cause, abnormal electroencephalogram and early onset seizures. Cognitive impairment was very common in CWE (64%) and was not associated with Phenobarbital use but was associated with motor difficulties, early onset and recurrent seizures. Poor school attendance was found in 56/112 (50%) of CWE, but not in the controls: it was associated with the presence of multiple co-morbidities, especially with motor difficulties in CWE.
conclusionChildren with epilepsy in a rural area of sub-Saharan Africa had a high level of co-morbidity. Cognitive impairment and poor school attendance were very common. These associated difficulties in CWE in the region need to be addressed to reduce the negative impact of epilepsy on these children.
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Registered trials
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