ArticleMedical science monitor : international medical journal of experimental and clinical research2011
Association between polymorphisms of XRCC1, p53 and MDR1 genes, the expression of their protein products and prognostic significance in human breast cancer.
Article in Medical science monitor : international medical journal of experimental and clinical research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 3 of them syntheses that pooled it.
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Who cites it
9 citing papers in PubMed, 3 syntheses or guidelines pooled it, 22 citations in OpenAlex.
- Systematic evaluation of TP53 codon 72 polymorphism associated with onset and progression of oral potentially malignant disorders.BMC oral health · 2023Pooled it
- A meta-analysis and experimental data for multidrug resistance genes in breast cancer.African health sciences · 2022Pooled it
- Association Between BRCA Status and P53 Status in Breast Cancer: A Meta-Analysis.Medical science monitor : international medical journal of experimental and clinical research · 2016Pooled it
- Recent Progress in the Regeneration of Spinal Cord Injuries by Induced Pluripotent Stem Cells.International journal of molecular sciences · 2019Review
- C3435T polymorphism in theInternational journal of clinical and experimental pathology · 2018Article
- Deregulation of base excision repair gene expression and enhanced proliferation in head and neck squamous cell carcinoma.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
- Cytoplasmic HuR expression correlates with P-gp, HER-2 positivity, and poor outcome in breast cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2013Article
- Detecting of breast cancer metastasis by means of regional lymph node sampling during autologous breast reconstruction--a screening of 519 consecutive patients.Medical science monitor : international medical journal of experimental and clinical research · 2012Article
- MicroRNA-10b targets E-cadherin and modulates breast cancer metastasis.Medical science monitor : international medical journal of experimental and clinical research · 2012Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis study aimed to examine the relationship between XRCC1, p53 and MDR1 protein, along with polymorphisms of their genes and their prognostic values in breast cancer. The following clinical and pathological parameters were evaluated: histopathological type of tumor, grade, stage, Her2/neu expression, ER, PR positivity and involvement of regional lymph nodes. MATERIAL/
methodsExpression of proteins was determined in 39 samples of breast cancer by immunohistochemistry. Nucleotide polymorphisms were analyzed by PCR-RFLP. For statistical analysis, chi-square test (Yates), Fisher's exact test, and correlation test were used to analyze the data.
resultsThe highest protein expression was immunohistochemically found in MDR1 protein, with 54% of samples testing positive. In addition, the evaluation of MDR1 expression revealed higher positive immunoreactivity in lobular (LIC) and other types of tumor in comparison to ductal (DIC) type. The expression of p53 and XRCC1 protein was equal, but lower compared to MDR1, both testing positive in 36% of all tissue samples. Comparison of XRCC1 protein and histopathological type of tumor revealed that DIC and LIC types were mostly XRCC1-negative, while other types, papillary and mucinous were more likely to be XRCC1-positive. Interestingly, when evaluating LIC samples separately, a negative correlation between the Her2/neu and expression of XRCC1 was detected. Apparently, all Her2/neu-positive samples were XRCC1-negative (6/86%). The correlation test indicated a negative correlation between Her2/neu-positive samples and XRCC1-negative specimens (r = 1, p < 0.05). Statistical analysis did not reveal a correlation of p53 expression with clinical and pathological parameters. Similarly, no statistically significant difference was found between the tested polymorphisms and protein expression.
conclusionsWe did not find statistically significant correlation between tested polymorphisms and their protein expression.
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