ReviewJournal of human hypertension2012
Hypertension and atrial fibrillation: epidemiology, pathophysiology and therapeutic implications.
Review in Journal of human hypertension, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Renal denervation for atrial fibrillation: a comprehensive updated systematic review and meta-analysis.Journal of human hypertension · 2022Pooled it
- Relationship Between Screening-Detected Atrial Fibrillation and Blood Pressure Levels in Elderly Hypertensive Patients: The OMRON Heart Study.Thrombosis and haemostasis · 2025Trial
- Monocyte Activation Drives Atrial Fibrillation in Hypertension.Cardiovascular drugs and therapy · 2026Article
- A New Paradigm for Atrial Fibrillation Ablation in Obesity Focusing on Substrate Remodeling and Patient-Centered Outcomes.Reviews in cardiovascular medicine · 2026Review
- Predictive Value of P-Wave Dispersion and P-Wave Peak Time for Development of Postoperative Atrial Fibrillation in Renal Transplant Recipients.Annals of transplantation · 2025Article
- Mechanisms underlying atrial fibrillation in chronic kidney disease.Journal of molecular and cellular cardiology · 2025Review
- Inflammasome Signaling in Cardiac Arrhythmias: Linking Inflammation, Fibrosis, and Electrical Remodeling.International journal of molecular sciences · 2025Review
- Hypertension Exacerbates Endothelial Dysfunction in Patients With Atrial Fibrillation.Journal of clinical hypertension (Greenwich, Conn.) · 2025Article
- Hypertension and Atrial Fibrillation: Bridging the Gap Between Mechanisms, Risk, and Therapy.Medicina (Kaunas, Lithuania) · 2025Review
- Deep learning assists early-detection of hypertension-mediated heart change on ECG signals.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Article
- Association of Cardiovascular Risk Factors With Major and Minor Electrocardiographic Abnormalities: A Report From the Cross-Sectional Phase of Tehran Cohort Study.Health science reports · 2025Article
- Exploring the bidirectional relationship between sleep disorders and atrial fibrillation: implications for risk stratification and management.The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · 2024Review
- Hyperuricemia as a Risk Factor in Hypertension among Patients with Very High Cardiovascular Risk.Healthcare (Basel, Switzerland) · 2023Article
- [Rehabilitation for atrial fibrillation : Impact on arrhythmia and cumulative risk factors].Herzschrittmachertherapie & Elektrophysiologie · 2023Review
- Prevalence of atrial fibrillation in a regional Victoria setting, findings from the crossroads studies (2001-2003 and 2016-2018).The Australian journal of rural health · 2023Article
- Brain and cardiovascular-related changes are associated with aging, hypertension, and atrial fibrillation.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2022Review
- Left Atrial Myocardium in Arterial Hypertension.Cells · 2022Review
- Imaging techniques for the assessment of adverse cardiac remodeling in metabolic syndrome.Heart failure reviews · 2022Review
- Prevalence and determinants of cardiac arrhythmias and conduction anomalies in adults aged ≥ 40 years in Jimma Town, Southwest of Ethiopia: a cross-sectional study.African health sciences · 2022Article
- Latest hypertension research to inform clinical practice in Asia.Hypertension research : official journal of the Japanese Society of Hypertension · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hypertension is one of the most important risk factors associated with atrial fibrillation (AF) and increased the risk of cardiovascular events in patients with AF. However, the pathophysiological link between hypertension and AF is unclear. Nevertheless, this can be explained by the hemodynamic changes of the left atrium secondary to long standing hypertension, resulting in elevated left atrium pressure and subsequently left atrial enlargement. Moreover, the activation of renin-angiotensin-aldosterone system (RAAS) activation in patients with hypertension induces left atrial fibrosis and conduction block in the left atrium, resulting in the development of AF. Accordingly, recent studies have shown that effective blockage of RAAS by angiotensin converting enzyme inhibitors or angiotensin receptor antagonist may be effective in both primary and secondary prevention of AF in patients with hypertension, although with controversies. In addition, optimal antithrombotic therapy, blood pressure control as well as rate control for AF are key to the management of patients with AF.
Indexed as
Identifiers
22129612What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.