ArticlePancreas2012
Transmembrane emp24 protein transport domain 6 is selectively expressed in pancreatic islets and implicated in insulin secretion and diabetes.
Article in Pancreas, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 28 citations in OpenAlex.
- Replacement of dietary saturated with unsaturated fatty acids is associated with beneficial effects on lipidome metabolites: a secondary analysis of a randomized trial.The American journal of clinical nutrition · 2023Trial
- Contribution of leukocyte telomere length to cardiovascular disease onset from genome-wide cross-trait analysis.Nature communications · 2025Article
- The Role ofInsects · 2024Article
- Bioinformatics Analysis of Next Generation Sequencing Data Identifies Molecular Biomarkers Associated With Type 2 Diabetes Mellitus.Clinical medicine insights. Endocrinology and diabetes · 2023Article
- RNA aptamers specific for transmembrane p24 trafficking protein 6 and Clusterin for the targeted delivery of imaging reagents and RNA therapeutics to human β cells.Nature communications · 2022Article
- Expression of TMED3 is independently associated with colorectal cancer prognosis.Experimental and therapeutic medicine · 2022Article
- The many hats of transmembrane emp24 domain protein TMED9 in secretory pathway homeostasis.Frontiers in cell and developmental biology · 2022Review
- TMED2/9/10 Serve as Biomarkers for Poor Prognosis in Head and Neck Squamous Carcinoma.Frontiers in genetics · 2022Article
- Article
- Inhibition of H3K27me3 Demethylases Promotes Plasmablast Formation.ImmunoHorizons · 2021Article
- Transmembrane emp24 domain proteins in development and disease.Genetics research · 2019Review
- The protein secretion modulator TMED9 drives CNIH4/TGFα/GLI signaling opposing TMED3-WNT-TCF to promote colon cancer metastases.Oncogene · 2019Article
- Transgene-associated human growth hormone expression in pancreatic β-cells impairs identification of sex-based gene expression differences.American journal of physiology. Endocrinology and metabolism · 2019Article
- A single transcription factor is sufficient to induce and maintain secretory cell architecture.Genes & development · 2017Article
- p24 family proteins: key players in the regulation of trafficking along the secretory pathway.Protoplasma · 2016Review
- Hepatic ALT isoenzymes are elevated in gluconeogenic conditions including diabetes and suppressed by insulin at the protein level.Diabetes/metabolism research and reviews · 2015Article
- TMED6-COG8 is a novel molecular marker of TFE3 translocation renal cell carcinoma.International journal of clinical and experimental pathology · 2015Article
- Identification of molecular tumor markers in renal cell carcinomas with TFE3 protein expression by RNA sequencing.Neoplasia (New York, N.Y.) · 2013Article
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
objectivesThe objective of the study was to identify pancreatic islet-selective gene(s) that may play a functional role in islet biology and diabetes development.
methodsThrough bioinformatics, we identified and cloned a pancreas-enriched complementary DNA encoding transmembrane emp24 protein transport domain 6 (TMED6) and examined its mRNA and protein expression in tissues and islet cell lines by Northern analysis and immunofluorescence histochemistry. We also studied the role of TMED6 in insulin secretion using a knockdown approach and its gene expression changes during the development of diabetes in Goto-Kakizaki rats.
resultsTMED6 is selectively expressed in pancreatic islets and belongs to the EMP24_GP25L superfamily, which is known to be involved in protein trafficking and secretion. Northern analysis revealed that TMED6 mRNA is highly and selectively expressed in pancreas. Immunofluorescence histochemistry of mouse pancreas showed that TMED6 expression is restricted to pancreatic islets with higher levels in α cells than β cells. Knockdown of TMED6 gene expression in Min6 β cells decreased insulin secretion. Moreover, TMED6 gene expression was significantly lower in diabetic Goto-Kakizaki rats.
conclusionsTMED6 may play a functional role in islet biology, particularly in hormone production or secretion, and its dysregulation may be implicated in the development of diabetes.
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