ReviewAnnual review of food science and technology2011
The influence of milk oligosaccharides on microbiota of infants: opportunities for formulas.
Review in Annual review of food science and technology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
78 citing papers in PubMed, 2 syntheses or guidelines pooled it, 174 citations in OpenAlex.
- Pooled it
- Systematic review of the concentrations of oligosaccharides in human milk.Nutrition reviews · 2017Pooled it
- Trial
- Early Effect of Supplemented Infant Formulae on Intestinal Biomarkers and Microbiota: A Randomized Clinical Trial.Nutrients · 2020Trial
- Human milk oligosaccharide concentration and risk of postnatal transmission of HIV through breastfeeding.The American journal of clinical nutrition · 2012Trial
- Early-life microbiota disruption-induced deficits in the social brain are sensitive to diet.iScience · 2026Article
- Impact ofNutrients · 2024Review
- Human milk oligosaccharides promote intestinal epithelium regeneration independent of the microbiota during necrotizing enterocolitis.Pediatric surgery international · 2024Article
- The involvement of oral bacteria in inflammatory bowel disease.Gastroenterology report · 2024Review
- A GC-MS-based untargeted metabolomics approach for comprehensive metabolic profiling of mycophenolate mofetil-induced toxicity in mice.Frontiers in molecular biosciences · 2024Article
- Chemical Synthesis of Human Milk Oligosaccharides: para-Lacto-N-hexaose and para-Lacto-N-neohexaose.Chemistry (Weinheim an der Bergstrasse, Germany) · 2023Article
- Article
- Determinants of human milk oligosaccharides profiles of participants in the STRONG kids 2 cohort.Frontiers in nutrition · 2023Article
- Early development of infant gut microbiota in relation to breastfeeding and human milk oligosaccharides.Frontiers in nutrition · 2023Article
- The role of human milk nutrients in preventing necrotizing enterocolitis.Frontiers in pediatrics · 2023Review
- Lactose-reduced infant formula with corn syrup solids and obesity risk among participants in the Special Supplemental Nutrition Program for Women, Infants, and Children (WIC).The American journal of clinical nutrition · 2022Article
- Human Milk Oligosaccharides and Lactose Differentially Affect Infant Gut Microbiota and Intestinal Barrier In Vitro.Nutrients · 2022Article
- Gut microbiota in various childhood disorders: Implication and indications.World journal of gastroenterology · 2022Review
- Solid-Phase Extraction Approaches for Improving Oligosaccharide and Small Peptide Identification with Liquid Chromatography-High-Resolution Mass Spectrometry: A Case Study on Proteolyzed Almond Extract.Foods (Basel, Switzerland) · 2022Article
- Role of milk carbohydrates in intestinal health of nursery pigs: a review.Journal of animal science and biotechnology · 2022Review
18 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
In addition to a nutritive role, human milk also guides the development of a protective intestinal microbiota in the infant. Human milk possesses an overabundance of complex oligosaccharides that are indigestible by the infant yet are consumed by microbial populations in the developing intestine. These oligosaccharides are believed to facilitate enrichment of a healthy infant gastrointestinal microbiota, often associated with bifidobacteria. Advances in glycomics have enabled precise determination of milk glycan structures as well as identification of the specific glycans consumed by various gut microbes. Furthermore, genomic analysis of bifidobacteria from infants has revealed specific genetic loci related to milk oligosaccharide import and processing, suggesting coevolution between the human host, milk glycans, and the microbes they enrich. This review discusses the current understanding of how human milk oligosaccharides interact with the infant microbiota and examines the opportunities for translating this knowledge to improve the functionality of infant formulas.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.