ArticleDiagnostic pathology2011
Methylation of cancer related genes in tumor and peripheral blood DNA from the same breast cancer patient as two independent events.
Article in Diagnostic pathology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 27 citations in OpenAlex.
- Machine learning unveils an immune-related DNA methylation profile in germline DNA from breast cancer patients.Clinical epigenetics · 2024Article
- Evaluation of BRCA1 Gene Promoter Methylation Status in Sporadic Breast Cancer Patients in Southwest of Iran.Asian Pacific journal of cancer prevention : APJCP · 2023Article
- Germline promoter hypermethylation in BRCA1 and BRCA2 genes is not present in hereditary breast cancer patients.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2018Article
- Methylation of BRCA1 and MGMT genes in white blood cells are transmitted from mothers to daughters.Clinical epigenetics · 2018Article
- Lifetime exposure to ambient air pollution and methylation of tumor suppressor genes in breast tumors.Environmental research · 2018Article
- Article
- DNA methylation as a promising landscape: A simple blood test for breast cancer prediction.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015Review
- Promoter Hypermethylation in White Blood Cell DNA and Breast Cancer Risk.Journal of Cancer · 2015Article
- The molecular significance of methylated BRCA1 promoter in white blood cells of cancer-free females.BMC cancer · 2014Article
- The ectopic expression of BRCA1 is associated with genesis, progression, and prognosis of breast cancer in young patients.Diagnostic pathology · 2012Article
- Article
- The limitations of locus specific methylation qualification and quantification in clinical material.Frontiers in genetics · 2012Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRecently it has been suggested that acquisition of methylation of the BRCA1 promoter detectable in peripheral blood (PB) DNA, could give raise to development of breast cancer. In this study, we aimed to investigate a relationship between methylation of three breast cancer related genes in PB DNA, and tumor specific (somatic) methylation of these genes in the same individual.
findingsWe have examined methylation status of the BRCA1, APC and RASSF1A promoter regions in a panel of 75 breast tumor and PB DNA samples from the same individual. In our study group, 4.0% of the patients displayed methylation of BRCA1 and APC in both tumor and the corresponding PB DNA. At the same time despite of marked methylation in tumor DNA, no methylation of BRCA1 and APC was seen in PB DNA of 4.3% and 2.7% of the patients respectively. The RASSF1A promoter did not show methylation in PB DNA.
conclusionsOur results show that for at least a subset of cancer patients methylation of certain cancer related genes in PB DNA does not seem to be directly linked to somatic methylation of the same genes in tumor DNA, and therefore may only be specific to PB DNA.
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