ArticleVeterinary research2011
Characterization of the abomasal transcriptome for mechanisms of resistance to gastrointestinal nematodes in cattle.
Article in Veterinary research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 56 citations in OpenAlex.
- Multimodal animal health monitoring in extensive livestock production systems.Frontiers in veterinary science · 2026Review
- Transcriptional Profiling of Abomasal Mucosa from Young Calves Experimentally Infected withInternational journal of molecular sciences · 2025Article
- Time-dependent RNA transcriptional profiling of abomasal mucosa in cattle infected with Ostertagia ostertagi.Scientific data · 2025Article
- A secreted helminth microRNA suppresses gastrointestinal cell differentiation required for innate immunity.Frontiers in immunology · 2025Article
- Unveiling Drimenol: A Phytochemical with Multifaceted Bioactivities.Plants (Basel, Switzerland) · 2024Review
- Multi-omics data elucidate parasite-host-microbiota interactions and resistance to Haemonchus contortus in sheep.Parasites & vectors · 2024Article
- Infection by a helminth parasite is associated with changes in DNA methylation in the house sparrow.Ecology and evolution · 2022Article
- Comparative analysis on lung transcriptome of Mycoplasma ovipneumoniae (Mo) - infected Bashbay sheep and argali hybrid sheep.BMC veterinary research · 2021Article
- Genomic variants from RNA-seq for goats resistant or susceptible to gastrointestinal nematode infection.PloS one · 2021Article
- Signatures of selection reveal candidate genes involved in economic traits and cold acclimation in five Swedish cattle breeds.Genetics, selection, evolution : GSE · 2020Article
- Systematic identification of long intergenic non-coding RNAs expressed in bovine oocytes.Reproductive biology and endocrinology : RB&E · 2020Article
- Transcriptome analysis unraveled potential mechanisms of resistance to Haemonchus contortus infection in Merino sheep populations bred for parasite resistance.Veterinary research · 2019Article
- Genome Analysis Reveals Genetic Admixture and Signature of Selection for Productivity and Environmental Traits in Iraqi Cattle.Frontiers in genetics · 2019Article
- Article
- DNA methylation patterns in peripheral blood mononuclear cells from Holstein cattle with variable milk yield.BMC genomics · 2018Article
- Identification of polymorphisms in the bovine collagenous lectins and their association with infectious diseases in cattle.Immunogenetics · 2018Article
- Exploring the mechanisms of resistance to Teladorsagia circumcincta infection in sheep through transcriptome analysis of abomasal mucosa and abomasal lymph nodes.Veterinary research · 2018Article
- Possible mechanisms of host resistance to Haemonchus contortus infection in sheep breeds native to the Canary Islands.Scientific reports · 2016Article
- Article
- Identification of large intergenic non-coding RNAs in bovine muscle using next-generation transcriptomic sequencing.BMC genomics · 2014Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The response of the abomasal transcriptome to gastrointestinal parasites was evaluated in parasite-susceptible and parasite-resistant Angus cattle using RNA-seq at a depth of 23.7 million sequences per sample. These cattle displayed distinctly separate resistance phenotypes as assessed by fecal egg counts. Approximately 65.3% of the 23,632 bovine genes were expressed in the fundic abomasum. Of these, 13,758 genes were expressed in all samples tested and likely represent core components of the bovine abomasal transcriptome. The gene (BT14427) with the most abundant transcript, accounting for 10.4% of sequences in the transcriptome, is located on chromosome 29 and has unknown functions. Additionally, PIGR (1.6%), Complement C3 (0.7%), and Immunoglobulin J chain (0.5%) were among the most abundant transcripts in the transcriptome. Among the 203 genes impacted, 64 were significantly over-expressed in resistant animals at a stringent cutoff (FDR < 5%). Among the 94 224 splice junctions identified, 133 were uniquely present: 90 were observed only in resistant animals, and 43 were present only in susceptible animals. Gene Ontology (GO) enrichment of the genes under study uncovered an association with lipid metabolism, which was confirmed by an independent pathway analysis. Several pathways, such as FXR/RXR activation, LXR/RXR activation, LPS/IL-1 mediated inhibition of RXR function, and arachidonic acid metabolism, were impacted in resistant animals, which are potentially involved in the development of parasite resistance in cattle. Our results provide insights into the development of host immunity to gastrointestinal nematode infection and will facilitate understanding of mechanism underlying host resistance.
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