ArticleJournal of natural products2011
Natural product libraries to accelerate the high-throughput discovery of therapeutic leads.
Article in Journal of natural products, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Natural Products Dereplication: Databases and Analytical Methods.Progress in the chemistry of organic natural products · 2024Review
- High-Throughput Screening of Natural Product and Synthetic Molecule Libraries for Antibacterial Drug Discovery.Metabolites · 2023Review
- Creating and screening natural product libraries.Natural product reports · 2020Review
- The Revaluation of Plant-Derived Terpenes to Fight Antibiotic-Resistant Infections.Antibiotics (Basel, Switzerland) · 2020Review
- Reinvestigation of Mycothiazole Reveals the Penta-2,4-dien-1-ol Residue Imparts Picomolar Potency and 8ACS medicinal chemistry letters · 2020Article
- Lysine Acetyltransferase Inhibitors From Natural Sources.Frontiers in pharmacology · 2020Review
- Review
- Discovery of human cell selective effector molecules using single cell multiplexed activity metabolomics.Nature communications · 2018Article
- Identification of the First Marine-Derived Opioid Receptor "Balanced" Agonist with a Signaling Profile That Resembles the Endorphins.ACS chemical neuroscience · 2017Article
- Metabolomics meets functional assays: coupling LC-MS and microfluidic cell-based receptor-ligand analyses.Metabolomics : Official journal of the Metabolomic Society · 2016Article
- Discovery and resupply of pharmacologically active plant-derived natural products: A review.Biotechnology advances · 2015Review
- Evaporative light scattering quantification of natural products possessing a carbon-phosphorus bond.The Journal of antibiotics · 2015Article
- Deguelins, Natural Product Modulators of NF1-Defective Astrocytoma Cell Growth Identified by High-Throughput Screening of Partially Purified Natural Product Extracts.Journal of natural products · 2015Article
- Alternative and efficient extraction methods for marine-derived compounds.Marine drugs · 2015Review
- UPLC-MS-ELSD-PDA as a powerful dereplication tool to facilitate compound identification from small-molecule natural product libraries.Journal of natural products · 2014Article
- Study of marine natural products including resorcyclic acid lactones from Humicola fuscoatra that reactivate latent HIV-1 expression in an in vitro model of central memory CD4+ T cells.Journal of natural products · 2014Article
- Matching the power of high throughput screening to the chemical diversity of natural products.Natural product reports · 2013Review
- Myxobacteria versus sponge-derived alkaloids: the bengamide family identified as potent immune modulating agents by scrutiny of LC-MS/ELSD libraries.Bioorganic & medicinal chemistry · 2012Article
- Microbial strain prioritization using metabolomics tools for the discovery of natural products.Analytical chemistry · 2012Article
- Universal quantification of structurally diverse natural products using an evaporative light scattering detector.Journal of natural products · 2012Article
Corrections and comments
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Authors and funding
22 authors.
Funding
Abstract
A high-throughput (HT) paradigm generating LC-MS-UV-ELSD-based natural product libraries to discover compounds with new bioactivities and or molecular structures is presented. To validate this methodology, an extract of the Indo-Pacific marine sponge Cacospongia mycofijiensis was evaluated using assays involving cytoskeletal profiling, tumor cell lines, and parasites. Twelve known compounds were identified including latrunculins (1-4, 10), fijianolides (5, 8, 9), mycothiazole (11), aignopsanes (6, 7), and sacrotride A (13). Compounds 1-5 and 8-11 exhibited bioactivity not previously reported against the parasite T. brucei, while 11 showed selectivity for lymphoma (U937) tumor cell lines. Four new compounds were also discovered including aignopsanoic acid B (13), apo-latrunculin T (14), 20-methoxy-fijianolide A (15), and aignopsane ketal (16). Compounds 13 and 16 represent important derivatives of the aignopsane class, 14 exhibited inhibition of T. brucei without disrupting microfilament assembly, and 15 demonstrated modest microtubule-stabilizing effects. The use of removable well plate libraries to avoid false positives from extracts enriched with only one or two major metabolites is also discussed. Overall, these results highlight the advantages of applying modern methods in natural products-based research to accelerate the HT discovery of therapeutic leads and/or new molecular structures using LC-MS-UV-ELSD-based libraries.
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