ArticleMolecular vision2011
Quantitative relationships between transforming growth factor beta mRNA isoforms in congenital and traumatic cataracts.
Article in Molecular vision, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed, 2 citations in OpenAlex.
- Intraocular cytokines imbalance in congenital cataract and its impact on posterior capsule opacification.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2016Article
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe aim of this study was to determine differences in the expression profiles of transforming growth factor (TGF) β isoforms in the fragments of anterior lens capsules (ALCs) and peripheral blood mononuclear cells (PBMCs) of pediatric patients with congenital and traumatic cataracts.
methodsForty children with congenital cataracts (19 girls and 21 boys) and 22 children with traumatic cataracts (six girls and 16 boys) participated in the study. Fragments of ALCs obtained during cataract surgery and whole blood samples were analyzed. Quantification of TGFβ1, TGFβ2, and TGFβ3 mRNA was performed by real-time quantitative reverse transcription (QRT)-PCR using SYBR Green I chemistry.
resultsTGFβ1, TGFβ2, and TGFβ3 mRNA was detected in all the studied samples. Significant differences were found for TGFβ1 and TGFβ2 expression profiles in PBMCs between the patients with congenital and traumatic cataracts. The expression profiles of TGFβ isoforms in ALCs did not differ significantly between the groups.
conclusionsOverexpression of TGFβ1 and TGFβ2 in the PBMCs of patients with congenital cataracts might indicate that these cytokines are involved in the development of lens opacity.
Indexed as
Identifiers
22128246PMC3224844W149987032What OpenQuestion holds
Registered trials
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