Evidence map›Paper›PMID 22128195›Full record

Trial reportCirculation. Cardiovascular imaging2012

Provider-directed imaging stress testing reduces health care expenditures in lower-risk chest pain patients presenting to the emergency department.

Chadwick D Miller, James W Hoekstra, Cedric Lefebvre, Howard Blumstein, Craig A Hamilton, Erin N Harper, Simon Mahler, Deborah B Diercks, Rebecca Neiberg, W Gregory Hundley

4 registry-linked trialsAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Circulation. Cardiovascular imaging, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 14 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00869245 nacompletednot on this map

Efficacy Evaluation of Observation Unit Cardiac Magnetic Resonance Imaging (MRI) in Patients With Intermediate Risk Acute Chest Pain

TypeinterventionalSponsorWake Forest University Health SciencesRan2009 to 2011Enrolled124ConditionsAcute Coronary Syndrome, Chest PainArmsOU - Cardiac MRI, OU - Conventional Care Testing
NCT01665521 nacompletednot on this map

Efficacy Evaluation of the HEART Pathway in Emergency Department Patients With Acute Chest Pain

TypeinterventionalSponsorWake Forest University Health SciencesRan2012 to 2018Enrolled282ConditionsAcute Coronary Syndrome, Chest PainArmsHEART Pathway
NCT01931852 nacompletednot on this mapstarted 2013, after this paper: background citation

Cardiac Magnetic Resonance Imaging Strategy for the Management of Patients With Acute Chest Pain and Detectable to Elevated Troponin

TypeinterventionalSponsorWake Forest University Health SciencesRan2013 to 2020Enrolled312ConditionsAcute Coronary Syndrome, Chest PainArmsCardiac MRI, ACC/AHA Guideline adherent care
NCT01953276 completednot on this mapstarted 2013, after this paper: background citation

Are Serial Electrocardiograms Additive to SeriAl Second-generations Troponins in Predicting Acute CoronAry Syndromes in PatienTs With Undifferentiated cHest Pain (ASAP CATH) Study

TypeobservationalSponsorWake Forest University Health SciencesRan2013 to 2018Enrolled382ConditionsAcute Coronary Syndrome, Chest PainArmsSerial Electrocardiograms
3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. The HEART Pathway Randomized Controlled Trial One-year Outcomes.Academic emergency medicine : official journal of the Society for Academic Emergency Medicine · 2019
    Trial
  6. Trial
  7. Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Reduction in observation unit length of stay with coronary computed tomography angiography depends on time of emergency department presentation.Academic emergency medicine : official journal of the Society for Academic Emergency Medicine · 2013
    Article
  13. Review
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Chadwick D MillerDepartment of Emergency Medicine, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA. cmiller@wfubmc.edu
James W Hoekstra
Cedric Lefebvre
Howard Blumstein
Craig A Hamilton
Erin N Harper
Simon Mahler
Deborah B Diercks
Rebecca Neiberg
W Gregory Hundley

Funding

Vascular Stiffness and Pulmonary CongestionR01HL076438 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI HUNDLEY, WILLIAM GREGORY · 2007 to 2011
$3.2M
Training Grant in Quality of Care and Outcomes Research in Cardiovascular DiseaseT32HL087730 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI GOFF, DAVID C · 2008 to 2011
$1.1M
Randomized Investigation of Chest Pain Diagnostic StrategiesR21HL097131 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI MILLER, CHADWICK DAVID · 2010 to 2011
$407k
NHLBI NIH HHS 1 R01 HL076438NHLBI NIH HHS 1 R21 HL097131-01A1NHLBI NIH HHS 5 T32 HL 87730NHLBI NIH HHS R01 HL076438NHLBI NIH HHS R21 HL097131NHLBI NIH HHS T32 HL087730
6 · The paper itself

Abstract

backgroundAmong intermediate- to high-risk patients with chest pain, we have shown that a cardiac magnetic resonance (CMR) stress test strategy implemented in an observation unit (OU) reduces 1-year health care costs compared with inpatient care. In this study, we compare 2 OU strategies to determine among lower-risk patients if a mandatory CMR stress test strategy was more effective than a physicians' ability to select a stress test modality. METHODS AND

resultsOn emergency department arrival and referral to the OU for management of low- to intermediate-risk chest pain, 120 individuals were randomly assigned to receive (1) a CMR stress imaging test (n=60) or (2) a provider-selected stress test (n=60: stress echo [62%], CMR [32%], cardiac catheterization [3%], nuclear [2%], and coronary CT [2%]). No differences were detected in length of stay (median CMR=24.2 hours versus 23.8 hours, P=0.75), catheterization without revascularization (CMR=0% versus 3%), appropriateness of admission decisions (CMR 87% versus 93%, P=0.36), or 30-day acute coronary syndrome (both 3%). Median cost was higher among those randomly assigned to the CMR-mandated group ($2005 versus $1686, P<0.001).

conclusionsIn patients with lower-risk chest pain receiving emergency department-directed OU care, the ability of a physician to select a cardiac stress imaging modality (including echocardiography, CMR, or radionuclide testing) was more cost-effective than a pathway that mandates a CMR stress test. Contrary to prior observations in individuals with intermediate- to high-risk chest pain, in those with lower-risk chest pain, these results highlight the importance of physician-related choices during acute coronary syndrome diagnostic protocols. CLINICAL

trial registrationURL: http://www.clinicaltrials.gov. Unique identifier: NCT00869245.

Indexed as

Emergency Service, HospitalAcute Coronary SyndromeAgedCardiac CatheterizationChest PainEchocardiographyExercise TestFemaleFollow-Up StudiesHealth ExpendituresHeartHumansLength of StayMagnetic Resonance ImagingMaleMiddle Aged

Identifiers

PMID22128195
PMCPMC3272279

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.