ArticleGenome research2012
Evolutionary history of novel genes on the tammar wallaby Y chromosome: Implications for sex chromosome evolution.
Article in Genome research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 33 citations in OpenAlex.
- Profile of Jennifer Marshall Graves.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Chromosome Evolution in Marsupials.Genes · 2018Review
- Y chromosome palindromes and gene conversion.Human genetics · 2017Review
- The Y chromosomes of the great apes.Human genetics · 2017Review
- Evolution of Dosage Compensation in Anolis carolinensis, a Reptile with XX/XY Chromosomal Sex Determination.Genome biology and evolution · 2017Article
- The pig X and Y Chromosomes: structure, sequence, and evolution.Genome research · 2016Article
- Weird mammals provide insights into the evolution of mammalian sex chromosomes and dosage compensation.Journal of genetics · 2015Review
- Paternal X inactivation does not correlate with X chromosome evolutionary strata in marsupials.BMC evolutionary biology · 2014Article
- Genetic regulation of mammalian gonad development.Nature reviews. Endocrinology · 2014Review
- Article
- Article
- Chromosome-wide profiling of X-chromosome inactivation and epigenetic states in fetal brain and placenta of the opossum, Monodelphis domestica.Genome research · 2014Article
- Efficient identification of Y chromosome sequences in the human and Drosophila genomes.Genome research · 2013Article
- No evidence for a second evolutionary stratum during the early evolution of mammalian sex chromosomes.PloS one · 2012Article
- Review
- Why chromosome palindromes?International journal of evolutionary biology · 2012Article
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Authors and funding
13 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We report here the isolation and sequencing of 10 Y-specific tammar wallaby (Macropus eugenii) BAC clones, revealing five hitherto undescribed tammar wallaby Y genes (in addition to the five genes already described) and several pseudogenes. Some genes on the wallaby Y display testis-specific expression, but most have low widespread expression. All have partners on the tammar X, along with homologs on the human X. Nonsynonymous and synonymous substitution ratios for nine of the tammar XY gene pairs indicate that they are each under purifying selection. All 10 were also identified as being on the Y in Tasmanian devil (Sarcophilus harrisii; a distantly related Australian marsupial); however, seven have been lost from the human Y. Maximum likelihood phylogenetic analyses of the wallaby YX genes, with respective homologs from other vertebrate representatives, revealed that three marsupial Y genes (HCFC1X/Y, MECP2X/Y, and HUWE1X/Y) were members of the ancestral therian pseudoautosomal region (PAR) at the time of the marsupial/eutherian split; three XY pairs (SOX3/SRY, RBMX/Y, and ATRX/Y) were isolated from each other before the marsupial/eutherian split, and the remaining three (RPL10X/Y, PHF6X/Y, and UBA1/UBE1Y) have a more complex evolutionary history. Thus, the small marsupial Y chromosome is surprisingly rich in ancient genes that are retained in at least Australian marsupials and evolved from testis-brain expressed genes on the X.
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