ArticleThe British journal of radiology2012
Multidetector CT features of pulmonary focal ground-glass opacity: differences between benign and malignant.
Article in The British journal of radiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 2 of them syntheses that pooled it.
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Who cites it
63 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The value of chest CT in the differential diagnosis of benign and malignant pulmonary nodules: a meta-analysis.Frontiers in medicine · 2026Pooled it
- Diagnostic value of computed tomography scanning in differentiating malignant from benign solitary pulmonary nodules: a meta-analysis.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Pooled it
- Nomogram based on clinical characteristics and radiological features for the preoperative prediction of spread through air spaces in patients with clinical stage IA non-small cell lung cancer: a multicenter study.Diagnostic and interventional radiology (Ankara, Turkey) · 2023Trial
- A Predictive Model Integrating AI Recognition Technology and Biomarkers for Lung Nodule Assessment.The Thoracic and cardiovascular surgeon · 2025Article
- A Novel Scale for Diagnosis of Pulmonary Ground-Glass Nodules: A Multicenter and Ambispective Cohort Study.The clinical respiratory journal · 2024Article
- Predicting the invasiveness of ground-glass opacity predominant lung adenocarcinoma with clinical stage Ia: a CT-based semantic and radiomics analysis.Journal of thoracic disease · 2024Article
- Bubble-like lucency in pulmonary ground glass nodules on computed tomography: a specific pattern of air-containing space for diagnosing neoplastic lesions.Cancer imaging : the official publication of the International Cancer Imaging Society · 2024Article
- CT-Based Intratumoral and Peritumoral Radiomics Nomograms for the Preoperative Prediction of Spread Through Air Spaces in Clinical Stage IA Non-small Cell Lung Cancer.Journal of imaging informatics in medicine · 2024Article
- [Value of CT Quantitative Parameters in Prediction of Pathological Types of Lung Ground Glass Nodules].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2024Article
- Establishing and validation of the VBV score for assessing Lung ground-glass nodules based on high-resolution computed tomography.Journal of cardiothoracic surgery · 2024Article
- Subsolid nodules, adenocarcinomas, and COVID-19: looking for needles in a haystack.Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia · 2024Article
- Clinical and non-contrast computed tomography characteristics and disease development in patients with benign pulmonary subsolid nodules with a solid component ≤ 5 mm.Insights into imaging · 2024Article
- Prediction of benign and malignant ground glass pulmonary nodules based on multi-feature fusion of attention mechanism.Frontiers in oncology · 2024Article
- Extracellular volume fraction as a potential predictor to differentiate lung cancer from benign lung lesions with dual-layer detector spectral CT.Quantitative imaging in medicine and surgery · 2023Article
- A nomogram for predicting invasiveness of lung adenocarcinoma manifesting as pure ground-glass nodules: incorporating subjective CT signs and histogram parameters based on artificial intelligence.Journal of cancer research and clinical oncology · 2023Article
- Correlation exploration among CT imaging, pathology and genotype of pulmonary ground-glass opacity.Journal of cellular and molecular medicine · 2023Article
- Ground glass nodules with scattered or eccentric island-shaped consolidations may have poor outcomes.Cancer innovation · 2023Article
- Quantitative evaluation of density variability in the lesion-lung boundary zone to differentiate pulmonary subsolid nodules.Quantitative imaging in medicine and surgery · 2023Article
- Analysis of the relevance between computed tomography characterization and pathology of pulmonary ground-glass nodules with different pathology types.Turk gogus kalp damar cerrahisi dergisi · 2023Article
- Potential Role of Intrapulmonary Concomitant Lesions in Differentiating Non-Neoplastic and Neoplastic Ground Glass Nodules.Journal of inflammation research · 2023Article
3 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate different features between benign and malignant pulmonary focal ground-glass opacity (fGGO) on multidetector CT (MDCT).
methods82 pathologically or clinically confirmed fGGOs were retrospectively analysed with regard to demographic data, lesion size and location, attenuation value and MDCT features including shape, margin, interface, internal characteristics and adjacent structure. Differences between benign and malignant fGGOs were analysed using a χ(2) test, Fisher's exact test or Mann-Whitney U-test. Morphological characteristics were analysed by binary logistic regression analysis to estimate the likelihood of malignancy.
resultsThere were 21 benign and 61 malignant lesions. No statistical differences were found between benign and malignant fGGOs in terms of demographic data, size, location and attenuation value. The frequency of lobulation (p=0.000), spiculation (p=0.008), spine-like process (p=0.004), well-defined but coarse interface (p=0.000), bronchus cut-off (p=0.003), other air-containing space (p=0.000), pleural indentation (p=0.000) and vascular convergence (p=0.006) was significantly higher in malignant fGGOs than that in benign fGGOs. Binary logistic regression analysis showed that lobulation, interface and pleural indentation were important indicators for malignant diagnosis of fGGO, with the corresponding odds ratios of 8.122, 3.139 and 9.076, respectively. In addition, a well-defined but coarse interface was the most important indicator of malignancy among all interface types. With all three important indicators considered, the diagnostic sensitivity, specificity and accuracy were 93.4%, 66.7% and 86.6%, respectively.
conclusionAn fGGO with lobulation, a well-defined but coarse interface and pleural indentation gives a greater than average likelihood of being malignant.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.