Evidence map›Paper›PMID 22128111›Full record

Observational studyOtolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery2012

High prevalence of hearing impairment in HIV-infected Peruvian children.

Christina K Chao, Josephine A Czechowicz, Anna H Messner, Jorge Alarcón, Lenka Kolevic Roca, Marsi M Larragán Rodriguez, César Gutiérrez Villafuerte, Silvia M Montano, Joseph R Zunt

Abstract readObservational Study
In one paragraph

Observational study in Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Hearing Assessment in HIV-Exposed-Uninfected Infants.Tropical medicine and infectious disease · 2026
    Article
  4. Article
  5. Article
  6. A Cross-Sectional Study of Audiological Assessment in HIV Positive Children.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Middle ear pathologies in children living with HIV: A scoping review.The South African journal of communication disorders = Die Suid-Afrikaanse tydskrif vir Kommunikasieafwykings · 2022
    Article
  12. Article
  13. Auditory neurophysiology reveals central nervous system dysfunction in HIV-infected individuals.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2020
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Christina K ChaoDepartment of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, California, USA.
Josephine A Czechowicz
Anna H Messner
Jorge Alarcón
Lenka Kolevic Roca
Marsi M Larragán Rodriguez
César Gutiérrez Villafuerte
Silvia M Montano
Joseph R Zunt

Funding

University of Washington/Fred Hutch Center for AIDS ResearchP30AI027757 · NIAID · UNIVERSITY OF WASHINGTON · PI Grace C. John-Stewart · 1988 to 2026
$104.9M
Fogarty International Clinical Research Scholars Support Center @ Vanderbilt-AAMCR24TW007988 · FIC · VANDERBILT UNIVERSITY · PI VERMUND, STEN H. · 2007 to 2011
$27.6M
Retrovial Infections of the Nervous System in PeruR01NS055627 · NINDS · UNIVERSITY OF WASHINGTON · PI ZUNT, JOSEPH RAYMOND · 2006 to 2010
$3.0M
FIC NIH HHS R24 TW007988NIAID NIH HHS P30 AI027757NINDS NIH HHS R01 NS055627
6 · The paper itself

Abstract

objectivesTo measure the prevalence and to identify risk factors of hearing impairment in human immunodeficiency virus-infected children living in Peru. STUDY

designCross-sectional observational study.

settingTwo public hospitals and 1 nonprofit center in Lima, Peru, between August 2009 and April 2010. SUBJECTS: A total of 139 HIV-infected children, ages 4 to 19 years.

methodsHearing impairment and otologic health were assessed with pure tone audiometry, tympanometry, and otoscopy. The primary outcome was hearing loss, defined as average threshold >25dB for 0.5, 1, 2, and 4 kHz, in one or both ears. Historical and socioeconomic information was obtained through parental survey and medical chart review. Statistical analysis included univariate analysis and multivariate logistic regression.

resultsFifty-four (38.8%) of 139 children had hearing impairment. On multivariate analysis, risk factors included: tympanic membrane perforation (odds ratio [OR] 7.08; 95% confidence interval [CI], 1.65-30.5; P = .01), abnormal tympanometry (OR 2.71; 95% CI, 1.09-6.75; P = .03), cerebral infection (OR 11.6; 95% CI, 1.06-126; P = .05), seizures (OR 5.20; 95% CI, 1.21-22.4; P = .03), and CD4 cell count <500 cells/mm(3) (OR 3.53; 95% CI, 1.18-10.5; P = .02).

conclusionsThe prevalence of hearing impairment in HIV-infected children in Lima, Peru was 38.8%. Middle ear disease, prior cerebral infection, and low CD4 cell count were significantly associated with hearing impairment. The high prevalence of hearing impairment emphasizes the need for periodic hearing assessment in the routine clinical care of HIV-infected children.

Indexed as

ChildChild, PreschoolCross-Sectional StudiesFemaleHearing LossHIV InfectionsHumansMalePeruPrevalenceRisk Factorshearing impairmentHIVPeru

Identifiers

PMID22128111
PMCPMC3593743

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.