ArticleEnvironmental health perspectives2012
In utero exposure to maternal tobacco smoke and subsequent obesity, hypertension, and gestational diabetes among women in the MoBa cohort.
Article in Environmental health perspectives, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 2 of them syntheses that pooled it.
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Who cites it
40 citing papers in PubMed, 2 syntheses or guidelines pooled it, 89 citations in OpenAlex.
- Air pollution and gestational diabetes mellitus: evidence from cohort studies.BMJ open diabetes research & care · 2020Pooled it
- Prenatal smoking exposure and cardio-metabolic risk factors in adulthood: a general population study and a meta-analysis.International journal of obesity (2005) · 2019Pooled it
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- Impact of maternal and offspring smoking and breastfeeding on oesophageal cancer in adult offspring.Nature communications · 2025Article
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- Maternal smoking during pregnancy links to childhood blood pressure through birth weight and body mass index: NHANES 1999-2018.Journal of human hypertension · 2024Article
- Involuntary tobacco smoke exposures from conception to 18 years increase midlife cardiometabolic disease risk: a 40-year longitudinal study.Journal of developmental origins of health and disease · 2023Article
- Early-life residential green spaces and traffic exposure in association with young adult body composition: a longitudinal birth cohort study of twins.Environmental health : a global access science source · 2023Article
- The methylation profile ofFrontiers in immunology · 2023Article
- Interactions among maternal smoking, breastfeeding, and offspring genetic factors on the risk of adult-onset hypertension.BMC medicine · 2022Article
- Nicotine Exposure during Rodent Pregnancy Alters the Composition of Maternal Gut Microbiota and Abundance of Maternal and Amniotic Short Chain Fatty Acids.Metabolites · 2022Article
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- Association of Urinary Strontium Levels with Pregnancy-induced Hypertension.Current medical science · 2021Article
- Immediate and durable effects of maternal tobacco consumption alter placental DNA methylation in enhancer and imprinted gene-containing regions.BMC medicine · 2020Article
- DNA methylation links prenatal smoking exposure to later life health outcomes in offspring.Clinical epigenetics · 2019Article
- Smoking during pregnancy increases chemerin expression in neonatal tissue.Experimental physiology · 2019Article
- In utero exposure to tobacco smoke, subsequent cardiometabolic risks, and metabolic syndrome among U.S. adolescents.Annals of epidemiology · 2018Article
- Cardiopulmonary consequences of gestational toxicant exposure: Symposium overview at the 56th annual SOT meeting, Baltimore, MD.Reproductive toxicology (Elmsford, N.Y.) · 2018Article
- Blood pressure in young adulthood and residential greenness in the early-life environment of twins.Environmental health : a global access science source · 2017Article
- Secondhand Smoke Exposure and Subclinical Cardiovascular Disease: The Multi-Ethnic Study of Atherosclerosis.Journal of the American Heart Association · 2016Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundEnvironmental factors influencing the developmental origins of health and disease need to be identified and investigated. In utero exposure to tobacco smoke has been associated with obesity and a small increase in blood pressure in children; however, whether there is a corresponding increased risk of conditions such as diabetes and hypertension during adulthood remains unclear.
objectiveOur goal was to assess the association of self-reported in utero exposure to tobacco smoke with the prevalence of obesity, hypertension, type 2 diabetes mellitus (T2DM), and gestational diabetes mellitus (GDM) in women 14-47 years of age.
methodsWe conducted a cross-sectional analysis of the Norwegian Mother and Child Cohort Study, which enrolled pregnant women in Norway from 1999 thorough 2008. Exposure to tobacco smoke in utero (yes vs. no) was ascertained on the baseline questionnaire (obtained at ~ 17 weeks' gestation); the outcomes were ascertained from the Medical Birth Registry of Norway and the questionnaire. Our analysis included 74,023 women.
resultsWomen exposed to tobacco smoke in utero had 1.53 times the odds of obesity [95% confidence interval (CI): 1.45, 1.61] relative to those unexposed, after adjusting for age, education, and personal smoking. After further adjustment for body mass index, the odds ratio for hypertension was 1.68 (95% CI: 1.19, 2.39); for T2DM 1.14 (95% CI: 0.79, 1.65); and for GDM 1.32 (95% CI: 1.10, 1.58) among exposed compared with unexposed.
conclusionsExposure to tobacco smoke in utero was associated with obesity, hypertension, and GDM in adult women. The possibility that the associations were attributable to unmeasured confounding cannot be excluded.
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