ArticleDevelopmental psychobiology2012
Role of age, post-training consolidation, and conjunctive associations in the ontogeny of the context preexposure facilitation effect.
Article in Developmental psychobiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
36 citing papers in PubMed, 53 citations in OpenAlex.
- Tests for learning and memory in rodent regulatory studies.Current research in toxicology · 2024Article
- Postnatal development of the relaxin-3 innervation of the rat medial septum.Frontiers in neuroscience · 2023Article
- A method for the selective depletion of microglia in the dorsal hippocampus in the juvenile rat brain.Journal of neuroscience methods · 2022Article
- Developmental emergence of persistent memory for contextual and auditory fear in mice.Learning & memory (Cold Spring Harbor, N.Y.) · 2021Article
- The effects of early-life immune activation on microglia-mediated neuronal remodeling and the associated ontogeny of hippocampal-dependent learning in juvenile rats.Brain, behavior, and immunity · 2021Article
- Neurobiology of Infant Fear and Anxiety: Impacts of Delayed Amygdala Development and Attachment Figure Quality.Biological psychiatry · 2021Review
- NMDA receptors and the ontogeny of post-shock and retention freezing during contextual fear conditioning.Developmental psychobiology · 2020Article
- Cholinergic rescue of neurocognitive insult following third-trimester equivalent alcohol exposure in rats.Neurobiology of learning and memory · 2019Article
- Translating Developmental Neuroscience to Understand Risk for Psychiatric Disorders.The American journal of psychiatry · 2019Review
- Neonatal ethanol exposure impairs long-term context memory formation and prefrontal immediate early gene expression in adolescent rats.Behavioural brain research · 2019Article
- Differential involvement of amygdalar NMDA receptors across variants of contextual fear conditioning in adolescent rats.Behavioural brain research · 2019Article
- Developmental Aspects of Glucose and Calcium Availability on the Persistence of Memory Function Over the Lifespan.Frontiers in aging neuroscience · 2019Review
- Impairment of the context preexposure facilitation effect in juvenile rats by neonatal alcohol exposure is associated with decreased Egr-1 mRNA expression in the prefrontal cortex.Behavioral neuroscience · 2018Article
- Neurocognitive Development of Motivated Behavior: Dynamic Changes across Childhood and Adolescence.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Review
- Age and experience dependent changes in Egr-1 expression during the ontogeny of the context preexposure facilitation effect (CPFE).Neurobiology of learning and memory · 2018Article
- Differential expression of the immediate early genes c-Fos, Arc, Egr-1, and Npas4 during long-term memory formation in the context preexposure facilitation effect (CPFE).Neurobiology of learning and memory · 2018Article
- Neonatal infection produces significant changes in immune function with no associated learning deficits in juvenile rats.Developmental neurobiology · 2017Article
- Antagonism of muscarinic acetylcholine receptors in medial prefrontal cortex disrupts the context preexposure facilitation effect.Neurobiology of learning and memory · 2017Article
- Differential involvement of the medial prefrontal cortex across variants of contextual fear conditioning.Learning & memory (Cold Spring Harbor, N.Y.) · 2017Article
- Infantile Amnesia: A Critical Period of Learning to Learn and Remember.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Review
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The context preexposure facilitation effect (CPFE) is a variant of contextual fear conditioning in which context learning and context-shock associations occur on separate occasions. The CPFE with an immediate shock emerges between Postnatal Day (PND) 17 and 24 in the rat and depends on hippocampal NMDA-receptor function in PND 24 rats (Schiffino et al. [2011] Neurobiology of Learning and Memory 95(2):190-198). This study investigated this ontogenetic effect further and reports three findings: First, the CPFE is absent on PND 19 but emerges modestly in rats given exposure on PND 21. Second, the absence of the CPFE on PND 17 does not reflect inability to consolidate the context-shock association established on the training day. Lastly, the CPFE on PND 24 requires exposure to the combined features of the context. These results are the first to show that the early development of contextual fear conditioning depends on conjunctive representations and that processes underlying the CPFE begin to emerge around PND 21 in the rat.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.