ArticleNucleic acids research2012
IndelFR: a database of indels in protein structures and their flanking regions.
Article in Nucleic acids research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Structural Dynamics Predominantly Determine the Adaptability of Proteins to Amino Acid Deletions.International journal of molecular sciences · 2023Article
- Expanded analyses of the functional correlations within structural classifications of glycoside hydrolases.Computational and structural biotechnology journal · 2021Article
- Article
- Contributions of substitutions and indels to the structural variations in ancient protein superfamilies.BMC genomics · 2018Article
- Characterization of parasite-specific indels and their proposed relevance for selective anthelminthic drug targeting.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2016Article
- Structural homology guided alignment of cysteine rich proteins.SpringerPlus · 2016Article
- MSAIndelFR: a scheme for multiple protein sequence alignment using information on indel flanking regions.BMC bioinformatics · 2015Article
- Nucleotide insertions and deletions complement point mutations to massively expand the diversity created by somatic hypermutation of antibodies.The Journal of biological chemistry · 2014Article
- LenVarDB: database of length-variant protein domains.Nucleic acids research · 2014Article
- Evolution of protein indels in plants, animals and fungi.BMC evolutionary biology · 2013Article
- SeqFIRE: a web application for automated extraction of indel regions and conserved blocks from protein multiple sequence alignments.Nucleic acids research · 2012Article
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Authors and funding
5 authors.
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Abstract
Insertion/deletion (indel) is one of the most common methods of protein sequence variation. Recent studies showed that indels could affect their flanking regions and they are important for protein function and evolution. Here, we describe the Indel Flanking Region Database (IndelFR, http://indel.bioinfo.sdu.edu.cn), which provides sequence and structure information about indels and their flanking regions in known protein domains. The indels were obtained through the pairwise alignment of homologous structures in SCOP superfamilies. The IndelFR database contains 2,925,017 indels with flanking regions extracted from 373,402 structural alignment pairs of 12,573 non-redundant domains from 1053 superfamilies. IndelFR provides access to information about indels and their flanking regions, including amino acid sequences, lengths, locations, secondary structure constitutions, hydrophilicity/hydrophobicity, domain information, 3D structures and so on. IndelFR has already been used for molecular evolution studies and may help to promote future functional studies of indels and their flanking regions.
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